A miniaturized optical tomography platform for volumetric imaging of engineered living systems
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Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Royal Soc Chemistry
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Volumetric optical microscopy approaches that enable acquisition of three-dimensional (3D) information from a biological sample are attractive for numerous non-invasive imaging applications. The unprecedented structural details that these techniques provide have helped in our understanding of different aspects of architecture of cells, tissues, and organ systems as they occur in their natural states. Nonetheless, the instrumentation for most of these techniques is sophisticated, bulky, and costly, and is less affordable to most laboratory settings. Several miniature imagers based on webcams or low-cost sensors featuring easy assembly have been reported, for in situ imaging of biological structures at low costs. However, they have not been able to achieve the ability of 3D imaging throughout the entire volumes for spatiotemporal analyses of the structural changes in these specimens. Here we present a miniaturized optical tomography (mini-Opto) platform for lowcost, volumetric characterization of engineered living systems through hardware optimizations as well as applications of an optimized algebraic algorithm for image reconstruction.
Açıklama
Anahtar Kelimeler
On-A-Chıp, Multıcellular Spheroıds, Organoıd Cultures, Mını-Mıcroscope, Cell Spheroıds, Reconstructıon, Cancer, Vascularızatıon, Bıosensor, Networks
Kaynak
Lab on A Chip
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
19
Sayı
4
