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Development and Characterization of Potato Starch-Pectin-Based Active Films Enriched With Juniper Berry Essential Oil for Food Packaging Applications
(Wiley, 2025) Bhatia, Saurabh; Jawad, Muhammad; Chinnam, Sampath; Al-Harrasi, Ahmed; Shah, Yasir Abbas; Khan, Talha Shireen; Al-Azri, Mohammed Said; Koca, Esra; Aydemir, Levent Yurdaer; Diblan, Sevgin; Mohan, Syam; Najmi, Asim; Khalid, Asaad; Khan, Mahbubur Rahman
The increasing demand for sustainable food packaging has driven the development of films based on biopolymers. However, enhancing their functional properties remains a challenge. In the current study, potato starch-pectin (PSP) composite films were fabricated and enriched with juniper berry essential oil (JBEO) to improve their physicochemical properties. The effects of incorporating different concentrations of JBEO (0.1%-1% v/v) on various properties of PSP-based films were evaluated, including surface color, transparency, barrier properties, scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), thermal analysis (TGA and DTA), antioxidant activity, and antimicrobial effectiveness. Increasing the level of JBEO led to a significant decrease in the moisture content, film transparency, and mechanical attributes, while an increase in thickness, water permeability, and film elongation was observed. SEM analysis also revealed morphological properties such as some spherical, bubble-like configuration and cracks on the surface due to an increase in JBEO concentration. TGA and DTA revealed lower weight loss in the initial cycles due to the addition of JBEO, and the thermal stability of the films improved. The antioxidant assays revealed a concentration-dependent increase in the radical scavenging capacity of the films from 11.31% to 17.28% for DPPH and from 3.06% to 25.53% for ABTS. Moreover, significant antibacterial and antifungal activity of the bioactive films was observed against P. aeruginosa, S. aureus, and C. albicans. These findings suggest that JBEO enhances the functional properties of PSP films, making them suitable for active food packaging applications.
The expanded theory of planned behavior for energy saving among academics in Romania, Bulgaria, Turkey, and Slovakia
(Nature Portfolio, 2025) Puiu, Silvia; Yilmaz, Sidika Ece; Udristioiu, Mihaela Tinca; Raganova, Janka; Raykova, Zhelyazka; Yildizhan, Hasan; Ameen, Arman
Given the escalating global energy consumption and the concurrent economic and energy crises, energy-saving behaviour must be adopted on a large scale. Universities that are energy-intensive institutions should be one of the institutions where energy-saving behaviour is widely adopted. Academics devote a substantial portion of their time to their offices, which leads to increased energy usage. However, no study has investigated academics' energy-saving behaviours in the literature. Most studies focus on students or employees in various organizations. Our study tries to cover the gap by examining the energy-saving behaviour of academics in four countries (Romania, Bulgaria, Turkey, and Slovakia) based on the expanded Theory of Planned Behaviour. A questionnaire was distributed to 228 academics from the four countries to gather data. The research hypotheses were tested using partial least squares structural equation modelling. The findings show that individual factors (attitude and perceived behaviour control) influence the energy-saving intention of academics but not the organisational factors due to the weak identification with their universities. The study offers valuable insights for policymakers seeking to promote energy-saving programs in academic institutions. The academics can be seen as role models for their students which emphasizes the need to study more their sustainable behaviours.
Microfluidic rapid isolation and electrochemical detection of S. pneumonia via aptamer-decorated surfaces
(Elsevier, 2025) Babaie, Zahra; Kibar, Gunes; Yesilkaya, Hasan; Amrani, Yassine; Dogan, Soner; Tuna, Bilge G.; Ozalp, Veli C.; Cetin, Barbaros
Background: S. pneumoniae is widely recognized as a leading cause of respiratory infections worldwide, often resulting in high mortality rates. However, the advent of microfluidic technologies has brought significant advancements, including the simplified, sensitive, cost-effective, and rapid approach to pneumococcal bacteremia detection. In this study, a microfluidic magnetic platform is presented for rapid isolation, and an electrode array is utilized for the electrochemical detection of S. pneumoniae. Aptamer-decorated surfaces were employed for both isolation and detection. For isolation, silica magnetic microparticles were synthesized and decorated with aptamer. Results: Isolation performance was assessed for phosphate-buffered saline (PBS) and blood samples for different concentrations of S. pneumoniae. Electrical impedance spectroscopy (EIS) with fabricated gold interdigitated electrodes (IDEs) decorated with aptamer was implemented for the detection of S. pneumoniae at different bacteria concentrations. The microfluidic platform performed bacteria isolation at comparable isolation efficiency with batch systems but at a much faster rate (isolation took about a minute, and the aptamer-decorated electrode array exhibited a limit of detection (LOD) at 962 CFU/mL and linear range between 104 and 107CFU/mL. Significance: Our method represents a significant advancement compared to previous reports. Our microfluidic platform can efficiently isolate 60 mu L of the bacteria sample within about one minute. The entire process takes about two minutes including the detection step. Furthermore, our method achieves a notable improvement in the detection limit for S. pneumoniae compared to conventional ELISA and magnetic microfluidics ELISA.
Synthesis and Photoluminescence Properties of Eu3+-Activated Ba2Cd(BO3)2 Red-Emitting Phosphors for Near-Ultraviolet Excited White Light-Emitting Diodes
(Wiley, 2025) Toreli, S. B.; Kafadar, V. E.; Emen, F. M.; Ozturk, E.; Altinkaya, R.
A new class of rare-earth doped borate phosphors, Ba2Cd(BO3)(2): xEu(3+) (x = 2, 3, 4, 5, and 6 mol%), was synthesized using the high-temperature solid-state reaction technique in air. X-ray diffraction (XRD) confirmed the phase formation of Ba2Cd(BO3)(2), while Fourier transform infrared spectroscopy (FT-IR) revealed the presence of trigonal [BO3] units. The surface morphology was studied using field emission scanning electron microscopy (FE-SEM), and energy dispersive spectroscopy (EDS) identified the elements. Photoluminescence (PL) analysis showed that the phosphors emitted at 592, 613, 652, and 701 nm, corresponding to the D-5(0) -> F-7(1), D-5(0) -> F-7(2), D-5(0) -> F-7(3), and D-5(0) -> F-7(4) transition of Eu3+ ions, respectively. The 613 nm red emission, from the D-5(0) -> F-7(2) transition, was strongest for the 6 mol% Eu3+ sample. The emission intensity increased with Eu3+ concentration, peaking at 6 mol%. CIE chromaticity, correlated color temperature (CCT), and color purity calculations showed acceptable color coordinates (0.6426 and 0.3548), a low CCT value (2355 K), and high purity (91.34%), making the 6 mol% Eu3+-doped phosphor ideal for red light in white light-emitting diodes (WLEDs).
Bond Performance of GFRP Bars in Glass and Basalt Fiber-Reinforced Geopolymer Concrete Under Hinged Beam Tests
(MDPI, 2025) Erturkmen, Duygu; Urunveren, Husamettin; Beycioglu, Ahmet; Ibadov, Nabi; Aruntas, Hueseyin Yilmaz; Garbacz, Andrzej
In recent years, researchers have focused on the usability of fiber-reinforced polymer (FRP) bars due to their lightweight, corrosion-resistant, and eco-friendly characteristics. Geopolymers, as low-carbon alternatives to traditional binders, aim to reduce CO2 emissions in concrete production. The bond strength between FRP bars and concrete is critical for the load-bearing capacity and deformation characteristics of reinforced elements. The objectives of this work are to investigate the bond performance of GFRP bars in chopped glass and basalt fiber-added geopolymer concrete using hinged beam tests. Since the hinged beam test accurately represents the behavior of real bending elements, this test method was selected as a main bonding test. Initially, three geopolymer mixtures with Ms modulus values of 1.2, 1.3, and 1.4 were prepared and tested. The mixture with a modulus of 1.2 Ms, achieving a compressive strength of 56.53 MPa, a flexural strength of 3.54 MPa, and a flow diameter of 57 cm, was chosen for beam production due to its optimal workability and strength. After mechanical and workability tests, SEM analysis was performed to evaluate its internal structure. For evaluating the bond performance of GFRP bars, 12 geopolymer beam specimens were prepared, incorporating varying fiber types (chopped glass fiber or basalt fiber) and embedment lengths (5 & Oslash; or 20 & Oslash;). Hinged beam tests revealed that the bond strengths of glass and basalt fiber-added mixtures were up to 49% and 37% higher than that of the control geopolymer concrete, respectively. It was concluded that incorporating fibers positively influenced the bond between geopolymer concrete and GFRP bars, with glass fibers proving more effective than basalt fibers. These findings enhance the understanding of bond mechanisms between GFRP bars and geopolymer concrete, emphasizing their potential for sustainable and durable construction in both industrial and scientific applications.
Production and Shielding Effectiveness Features of Chopped Strands Backed-GdMnO3 Composites for 6.5-17.5 GHz Applications
(MDPI, 2025) Emek, Mehriban; Sahin, Ethem Ilhan; Ibrahim, Jamal Eldin F. M.
This research investigates the synthesis and characterization of GdMnO3/chopped strands composites using the conventional oxide mixing technique. A single-phase GdMnO3 compound was successfully formed through sintering at 1350 degrees C for 20 h. Structural analysis using X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDS) confirmed phase purity and uniform grain morphology. The microwave shielding effectiveness of GdMnO3/chopped strands composites was evaluated within the 6.5-17.5 GHz frequency range using a network analyzer (NA). The GdMnO3/chopped strands composite with a 60-40% weight ratio exhibited superior shielding performance, achieving a minimum shielding effectiveness of -35.61 dB at 6.9 GHz, while the 80-20% composite reached -32.54 dB at 16.74 GHz. Both compositions demonstrated shielding effect values below -10 dB across wide frequency bands, with significant attenuation below -20 dB at various GHz ranges. The study demonstrates that by adjusting the content of the components in the samples, the microwave shielding effect performance of the GdMnO3/chopped strands composites can be easily controlled to meet the requirements of specific frequency bands. These findings highlight the potential of GdMnO3-based composites for tailored microwave shielding applications, particularly in the military, aerospace, and telecommunication industries.
Expanding the role of exosomes in drug, biomolecule, and nanoparticle delivery
(Pergamon-Elsevier Science Ltd, 2025) Saka, Ongun Mehmet; Dora, Devrim Demir; Kibar, Gunes; Tevlek, Atakan
Exosomes are nanoscale extracellular vesicles released by diverse cell types, serving essential functions in intercellular communication and physiological processes. These vesicles have garnered considerable interest in recent years for their potential as drug delivery systems, attributed to their natural origin, minimal immunogenicity, high biocompatibility, and capacity to traverse biological barriers, including the blood-brain barrier. Exosomes can be obtained from diverse biological fluids, rendering them accessible and versatile vehicles for therapeutic medicines. This study emphasizes the burgeoning significance of exosomes in drug administration, concentrating on their benefits, including improved stability, target selectivity, and the capacity to encapsulate various biomolecules, such as proteins, nucleic acids, and small molecules. Notwithstanding their potential applications, other problems remain, including as effective drug loading, industrial scalability, and the standardization of isolation methodologies. Overcoming these hurdles via new research is essential for fully harnessing the promise of exosomes in therapeutic applications, especially in the treatment of intricate diseases like cancer and neurological disorders.
An Investigation of the Usability of Alkali-Activated Blast Furnace Slag-Additive Construction Demolition Waste as Filling Material
(MDPI, 2025) Sarici, Talha; Geckil, Tacettin; Ok, Bahadir; Aksoy, Huseyin Suha
In this study, the usability of construction and demolition waste (CDW) aggregates as filling when stabilized with alkaline activator solution (AAS) and blast furnace slag (BFS) was investigated. The initial stage of this study involved determining the engineering properties of CDW by laboratory experiments. In the next stage, modified Proctor tests were performed to investigate the compaction behavior of CDW, to which 5% to 30% BFS was added with water or AAS. In the following stage, California bearing ratio experiments were performed to determine the mixture specimen with the highest strength. In the final stage, a weak soil layer was created in a test tank, and fillings of different thicknesses were built on it using CDW with and without additives in the determined optimum mixing ratio. Then, plate-loading tests were conducted using a model foundation to evaluate the load-deformation behavior of the fillings. The study's results indicated that adding BFS with water or AAS to CDW increased strength. Furthermore, the addition of 20% BFS yielded the highest strength value, and the CDW aggregates with the added BFS increased the ultimate bearing capacity by up to 4.72 times compared to those without the additive.
Molecular Weight-Dependent Boron Release Effect in PVA/Chitosan Cryogels and In Vitro Mineralization Evaluations by Osteoblast Cells
(Wiley, 2025) Ceylan, Seda; Arici, Sule; Ege, Duygu; Yang, Ying
Cryogels were fabricated by combining polyvinyl alcohol (PVA) and chitosan of varying molecular weights (Mw). In this study, the effects of chitosan Mw, types of boron-containing molecules on network formation, and boron release rate in resulted cryogels were investigated. The PVA/chitosan blend maintained a constant 4.5% (w/v) polymer content. PVA to chitosan weight ratio of 6:1 was maintained and fixed. Five percent w/w boric acid and borax (sodium tetraborate) crosslinkers were added in PVA and chitosan mixtures to construct cryogels. The freeze-dried specimens underwent crosslinking evaluation, chemical composition analysis by FTIR, and boron release studies by ICP-MS. The pore morphology and the swelling capacity of the cryogel have been assessed by SEM and incubation in water, respectively. Mechanical test was also used to evaluate the effect of borax and Mw of chitosan on cryogels' mechanical properties. It was demonstrated that the types of boron supply had a significant role on the cryogelation capability. For different chitosan Mw, the cryogels made using borax showed stable cryogels. In contrast, even after altering the chitosan Mw, the formula with boric acid was unable to create stable cryogels. In addition, boron release assay showed that the quantity of free boron in the incubation solutions decreased as the Mw of the chitosan component of the cryogel was reduced. Cell culture studies with MC3T3-E1 pre-osteoblast cells in the cryogels indicated that borax-crosslinked samples exhibited sustained cell viability. Alizarin red staining assay was used to study mineralization capacity of boron-containing hydrogels, which confirmed increase of mineralization in low molecular weight chitosan groups.
Comparison of PDE-5 inhibitors used in erectile dysfunction with some candidate molecules: A study involving molecular docking, ADMET, DFT, biological target, and activity
(BMC, 2025) Sagir, Suleyman; Unsal, Velid; Oner, Erkan; Yildiz, Resit; Mert, Basak Dogru
Erectile dysfunction (ED) is a urological condition defined as the inability of a man to achieve or maintain an erection. This condition negatively affects his sexual performance and the performance of his partner. Phosphodiesterase type 5 (PDE5) inhibitors are commonly used to treat ED. Arginase II plays an important role in regulating L-arginine to NO synthase in the smooth muscle of the human corpus cavernosum of the penis. NO is a molecule essential for regulating a variety of functions, including arterial blood pressure, penile erection, and energy balance. Substances such as vardenafil, alprostadil, papaverine, and resveratrol increase NO production, thereby supporting sexual function and vascular health. Additionally, NO donors such as L-arginine, L-citrulline, and alpha-lipoic acid provide effective alternatives when used in combination with PDE5 inhibitors. Medications used in the treatment of ED include vardenafil, alprostadil, and papaverine. In addition, although molecules such as L-arginine, citrulline, resveratrol, alpha-lipoic acid, and rutin are thought to play a role in ED, their pharmacological and molecular effects have not been sufficiently elucidated. The aim of this study was to investigate the effects of these molecules in the treatment of ED by computer-based calculations, to obtain new information about them and to inspire new treatment strategies for ED. The physicochemical, molecular and pharmacokinetic properties of the compounds were determined by SwissADME software, and ADMET (absorption, distribution, metabolism, excretion and toxicity) data were determined by ADMETlab 3.0 software. Biological target and activity data were obtained by MolPredictX and PASS Online software. While the Gaussian 09 program was used for DFT calculations, PyMOL, AutodockTools 4.2.6, AutoDock Vina, and Biovia Discovery programs were used for molecular docking studies. It was found that L-arginine, citrulline, resveratrol and alpha-lipoic acid were well absorbed from the intestine, while rutin showed limited absorption. When their metabolic risks were evaluated, L-arginine and citrulline were found to have lower toxicity. Molecular docking results of rutin and resveratrol were remarkable. The electronic properties of the compounds were explained by DFT calculations. L-arginine and citrulline were found to have low toxicity and positive therapeutic effects. L-arginine and citrulline stand out as promising candidates for future research. Although resveratrol data are promising, unfortunately their potential toxicity and metabolic interactions require further investigation. It is important to learn more about these compounds or conduct research to improve their therapeutic efficacy. Although computer-based calculations play an important role in toxicity predictions, drug interactions, pharmacokinetics and toxicity properties should be carefully evaluated.
Comparison of new secondgeneration H1 receptor blockers with some molecules; a study involving DFT, molecular docking, ADMET, biological target and activity
(BMC, 2025) Unsal, Velid; Oner, Erkan; Yildiz, Resit; Mert, Basak Dogru
Although the antiallergic properties of compounds such as CAPE, Melatonin, Curcumin, and Vitamin C have been poorly discussed by experimental studies, the antiallergic properties of these famous molecules have never been discussed with calculations. The histamine-1 receptor (H1R) belongs to the family of rhodopsin-like G-protein-coupled receptors expressed in cells that mediate allergies and other pathophysiological diseases. In this study, pharmacological activities of FDA-approved second generation H1 antihistamines (Levocetirizine, desloratadine and fexofenadine) and molecules such as CAPE, Melatonin, Curcumin, Vitamin C, ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicity) profiles, density functional theory (DFT), molecular docking, biological targets and activities were compared by calculating. Since drug development is an extremely risky, costly and time-consuming process, the data obtained in this study will facilitate and guide future studies. It will also enable researchers to focus on the most promising compounds, providing an effective design strategy. Their pharmacological activity was carried out using computer-based computational techniques including DFT, molecular docking, ADMET analysis, biological targeting, and activity methods. The best binding sites of Desloratadine, Levocetirizine, Fexofenadine, CAPE, Quercetin, Melatonin, curcumin, Vitamin C ligands to Desmoglein 1, Human Histamine H1 receptor, IgE and IL13 protons were determined by molecular docking method and binding energy and interaction states were analyzed. Fexofenadine and Quercetin ligand showed the most effective binding affinity. Melatonin had the best Caco-2 permeability PPB values of Quercetin, CAPE and Curcumin were at optimal levels. On the OATP1B1 and OATP1B3 of curcumin and CAPE, Quercetin was found to have strong inhibition effects on BCRP. Melatonin and CAPE were found to have the highest inhibition values on CYP1A2, while CAPE had the highest inhibition values on CYP2C19 and CYP2C9. Vitamin C and Quercetin were found to be safer in terms of cardiac toxicity and mutagenic risks, while Desloratadine and Levocetirizine carried high risks of neurotoxicity and hematotoxicity, while CAPE was noted for its high enzyme inhibitory activities and low toxicity profiles, while the hERG blockade, DILI, and cytotoxicity values of other compounds pointed to various safety concerns. This study demonstrated the potential of machine learning methods in understanding and discovering H1 receptor blockers. The results obtained provide important clues in the development of important strategies in the clinical use of H1 receptor blockers. In the light of these data, CAPE and Quercetin are remarkable molecules.
Evaluation of extra virgin olive oil compounds using computational methods: in vitro, ADMET, DFT, molecular docking and human gene network analysis study
(BMC, 2025) Unsal, Velid; Yildiz, Resit; Korkmaz, Aziz; Mert, Basak Dogru; Caliskan, Cemile Gunbegi; Oner, Erkan
This study investigates the phenolic compounds (PC), volatile compounds (VC), and fatty acids (FA) of extra virgin olive oil (EVOO) derived from the Turkish olive variety Sar & imath; Ulak, along with ADMET, DFT, molecular docking, and gene network analyses of significant molecules identified within the EVOO. Chromatographic methods (GC-FID, HPLC) were employed to characterize FA, PC, and VC profiles, while quality parameters, antioxidant activities (TAC, ABTS, DPPH) were assessed via spectrophotometry. The analysis revealed a complex composition of 40 volatile compounds, with estragole, 7-hydroxyheptene-1, and 3-methoxycinnamaldehyde as the primary components. Hydroxytyrosol, tyrosol, oleuropein, apigenin, ferulic acid, and vanillic acid emerged as main phenolic constituents, with hydroxytyrosol and apigenin exhibiting high bioavailability. Molecular docking highlighted oleuropein and pinoresinol as compounds with strong binding affinities, though only hydroxytyrosol, apigenin, and pinoresinol fully met Lipinski and other drug-likeness criteria. DFT analysis showed that oleuropein and pinoresinol have notable dipole moments, reflecting polar and asymmetrical structures. KEGG enrichment analysis further linked key molecules like oleuropein and apigenin with pathways related to lipid metabolism and atherosclerosis, underscoring their potential bioactivity and relevance in health-related applications.
Comparative elucidation of the phenolic profile and antioxidant and antimicrobial activities of unripe and ripe Pistacia lentiscus L. fruits and their oils as affected by ripening
(Wiley, 2025) Buyukkurt, Ozlem Kilic; Guclu, Gamze; Kelebek, Hasim; Selli, Serkan
BackgroundPhenolic compounds, antioxidant activity, and antimicrobial properties of unripe and ripe mastic tree (Pistacia lentiscus L.) fruits and their oils were investigated.ResultsA total of 20 phenolic compounds were identified by using liquid chromatography-diode array detection and electrospray ionization tandem mass spectrometry, among which phenolic acids were predominant. The main phenolic compound was catechin in the unripe fruit and trigalloylquinic acid in the unripe fruit oil, whereas galloylquinic acid was dominant in the ripe fruit and its oil. Unripe fruits had the highest amount of total phenolic content (TPC; 2771.4 mg kg-1), whereas the ripe fruit oils had the lowest TPC (14.1 mg kg-1). The quantity of the phenolics decreased as the fruits ripened. Tests revealed significant antimicrobial activity of the fruit extracts against Staphylococcus aureus but not on Escherichia coli, whereas fruit oils showed no antimicrobial effects.ConclusionThe fruits and their oils exhibited significant alterations in phenolic composition, antioxidant activity, and antimicrobial effects during ripening. These findings highlight the impact of ripeness on the bioactive properties of mastic tree fruits and their potential applications in the food and pharmaceutical industries. (c) 2025 Society of Chemical Industry.
Evaluation of the Relationship Between Thyroid Hormone Levels and Bisphenol A in Children Aged 6-14 Years
(Wiley, 2025) Yildirim, Pinar Altun; Nazlican, Ersin; Haytoglu, Zeliha; Turan, Ihsan; Kilincli, Betul; Aydin, Asli Atasoy; Mengen, Eda; Daglioglu, Nebile
BackgroundThe incidence of hypothyroidism in childhood is increasing. This study aimed to investigate the potential role of exposure to bisphenol A, an environmental endocrine disruptor, and its substitutes in the development of hypothyroidism. To this end, thyroid hormone levels and urinary bisphenol concentrations were compared in newly diagnosed hypothyroid children and a healthy control group. MethodsIn this case-control study, 51 newly diagnosed hypothyroid children aged 6-14 years were matched with 51 healthy controls. The association between thyroid hormone levels and urinary bisphenol levels was investigated by measuring urinary bisphenol levels in both the case and control groups. ResultsThere was no significant difference in age, sex or BMI percentile between the case and control groups. The groups were homogeneously distributed. When urinary bisphenol levels were examined, BPA, BPS, BPF and BPB were not detected in the control group. There was a significant difference between the groups in terms of urinary bisphenol BPS levels. The case group showed a mean total concentration of 16.5 ng/mL and a median of 5.8 ng/mL. Diagnosing hypothyroidism in the children can be considered by examining the bisphenol level. In the ROC analysis, if this level is over 1.3 and is considered positive for hypothyroidism, the sensitivity value is determined as 83.7% and the specificity value is 75%. ConclusionThis study demonstrated that at least 50% of the children in the case group had bisphenol concentrations exceeding the highest value recorded in the control group, suggesting that total BP levels could be used as a potential biomarker for hypothyroidism.
Bolanthus turcicus: a promising antidiabetic with in-vitro antioxidant, enzyme inhibitory and antiadipogenic activities
(Springer, 2025) Ozdas, Sibel; Canatar, Ipek; Derici, Gizem Ece; Koc, Murat
It is crucial to investigate new anti-diabetic agents and therapeutic approaches targeting molecules in potential signaling pathways for the treatment of Type 2 diabetes mellitus (T2DM). The objective of the study was to investigate the total phenolic content, antioxidant capacity, alpha-glucosidase, and alpha-amylase inhibitory activities of Bolanthus turcicus (B. turcicus), as well as their cytotoxic, anti-adipogenic, anti-diabetic, apoptotic, and anti-migration potential on adipocytes. B. turcicus samples were extracted with methanol (MeOH), ethyl acetate (EA) and aqueous (Aq) solvents. The MeOH extract had the highest phenolic content (81.14 mg GAE/g), followed by EA (74.93 mg GAE/g) and Aq (51.09 mg GAE/g). All extracts exhibited dose-dependent increases in alpha-glycosidase and alpha-amylase inhibitory activity. B. turcicus extracts showed cytotoxic effect on adipocytes with IC50 values of MeOH (141.0 mu g/mL) < Aq (155.3 g/mL) < EA (199.5 g/mL). Furthermore, B. turcicus extracts reduced lipid droplet formation and adipocyte diameter size. All extracts altered cell morphology to resemble fibroblasts. B. turcicus extracts exhibited anti-migratory effect delaying wound healing for up to 96 h. The B. turcicus extracts showed a pro-apoptotic effects on adipocytes by increasing Caspase-3 enzyme activity and the population of DAPI-positive cell with apoptotic nuclear-morphology. B. turcicus extracts upregulated the expression of the Glut-4 gene at the mRNA, protein and intracellular level in adipocytes. In conclusion, our findings indicate that B. turcicus not only exhibits strong antioxidant properties and enzyme inhibitory activities but also exerts significant anti-adipogenic and pro-apoptotic effects in adipocytes, thereby providing a comprehensive mechanism through which it may contribute to the management of T2DM. These effects highlight the potential of B. turcicus as a therapeutic agent for improving glucose homeostasis and insulin sensitivity.
Exploring the effects of perceived social support and psychological distress through mediation and multigroup analyses in work-related quality of life
(Nature Portfolio, 2025) Yilmaz, Sidika Ece; Citak, Senel
Work-related quality of life has emerged as a central focus in the field of occupational health due to its impact on individual well-being and overall quality of life. So, it is crucial to enhance the current theory by conducting a study on the concept across different sectors. Also, the specific mechanisms through which perceived social support influences work-related quality of life remain underexplored. The role of psychological distress as a potential mediator in this relationship has not been investigated. Thus, the study aimed to explore the mediating role of psychological distress in this relationship, while also examining potential gender differences. The study, conducted with 401 teachers through a questionnaire, utilized the AMOS program for data analysis. The findings supported the direct effects among the variables and the mediating role of psychological distress. Additionally, the impact of psychological distress on work-related quality of life was found to be higher for females, but no differences for other paths. The study contributes to the literature by addressing the gap in understanding the mechanisms regarding work-related quality of life. The results highlight the importance of considering psychological distress and gender differences in interventions aimed at improving work-related quality of life.
Institutional logics, social interactions and management of tensions in public-private partnership organizations
(Emerald Group Publishing Ltd, 2025) Danisman, Ali; Ozseven, Mustafa
PurposeWe aim to understand the link between field-level institutional logics and practice-level social interactions and relationships between public and private actors and their influences on the responses and resolutions to the issues causing tensions.Design/methodology/approachAdopting a multiple logics perspective with a focus on social interactions and relationships between public and private actors, we conducted a multiple case study in five city hospitals recently established under a public-private partnership model in the Turkish healthcare field.FindingsWe found that the state and market logics that predominantly characterize the Turkish healthcare field were enacted in each of the five hospitals in different manners and constitute three different configurations as compatible, complementary and contradictory. The social interactions and relationships developed between the public and private actors occur based on these configurations, and they all together shape the responses and resolutions to the issues causing tensions.Research limitations/implicationsSince we did all analyses between the organizational actors at the partnership level, we did not consider possible differences arising from individual and positional roles in each partnership. It is therefore important to acknowledge that the interviews, which are central to the research results, might be influenced by the motivation and power dynamics of the participants in terms of their positions, roles and responsibilities. Thus, much work must be done to understand the management of tensions in public-private partnership organizations (PPPOs) influenced by institutional logics with a greater focus on individual, partnership, organizational and field-level interactions.Practical implicationsTensions arising between public and private actors in PPPOs can be understood better and managed more effectively when the enactment of institutional logics is considered together with their social interactions and relationships.Originality/valueThe novelty of our study is that we advance the knowledge on the management of tensions in PPPOs by empirically showing the link between field-level institutional logics and practice-level social interactions and relationships and their influences on the responses and resolutions to the issues causing tensions. Our results indicate that tensions arising between public and private actors in PPPOs are primarily responded to by private actors mainly with avoidance, defiance or decoupling and subsequently resolved by their joint efforts through informal collaboration, formalization, formalized collaboration, enforcement or coercive pressure, depending on how the state and market logics are enacted within the hospitals and how social interactions and relationships between public and private side actors are formed accordingly.
Changes in volatile, key odorants and bioactive properties of pomegranate juice during processing into concentrate
(Elsevier Sci Ltd, 2025) Salman, Eda; Guclu, Gamze; Pehlivan, Zeynep Yaren; Kelebek, Hasim; Selli, Serkan
Key odorants of juices of pomegranate fruits of Hicaz variety obtained from different juice production stages (fresh: FrPJ, pasteurized: PPJ, filtered: FiPJ, and concentrated: CPJ) were examined. Processing significantly impacted the volatile compounds. The FrPJ and PPJ samples had higher concentrations of aroma compounds than the FiPJ and CPJ samples. A total of 38 aroma substances were identified in the FrPJ sample while 37, 35, and 21 compounds were detected in the PPJ, FiPJ, and CPJ samples, respectively. Phenylethyl alcohol was the dominant key odorant. The total phenolic contents (TPC) and antioxidant activities (AA) of the samples changed significantly. The CPJ sample had the highest TPC and AA due to increased release of phenolics during the concentration process; thus, this process increased the TPC and AA significantly, altering both aroma and bioactive properties. The results emphasize the importance of processing methods in preserving the nutritional and sensory qualities of pomegranate juice.
Advancing wound healing: controlled release of tannic acid via epitope imprinted antimicrobial spongy cover material
(Springer, 2025) Tuna, Busra; Arisoy, Piril; Oktay Basegmez, Hatice Imge; Pesint, Gozde Baydemir
The increasing resistance of microorganisms to conventional antibiotics calls for alternative antimicrobial strategies. This study introduces a novel approach to acute wound healing by incorporating epitope-imprinted spongy cover materials with antimicrobial properties, using Tannic acid (TA) as the active agent within biocompatible cryogels imprinted with gallic acid. The spongy materials were synthesized and characterized through Fourier Transform Infrared Spectroscopy (FTIR), swelling tests, and Scanning Electron Microscopy (SEM) to assess their structural and physicochemical properties. The antimicrobial efficacy of the cryogels, loaded with 1.5, 3, 5 mg/mL of TA concentrations, was tested against Staphylococcus aureus and Escherichia coli, common pathogens in wound infections. The highest inhibition zone was determined to be 15 mm for S. aureus and 12 mm for E. coli. Maximum TA adsorption was 210.27 mg/g for eMIP and 24.74 mg/g for NIP. Cumulative release studies revealed the highest release rate occurred within the first 2 h. TA release kinetics indicated a non-Fickian diffusion mechanism. Additionally, the biocompatibility and potential cytotoxicity of the spongy materials, including TA-loaded variants, were assessed using the MTT assay on cultured cells. The results confirmed that the spongy materials are non-toxic and do not inhibit cell proliferation, supporting their suitability for acute wound healing. This study demonstrates that TA-loaded epitope-imprinted Poly(2-hydroxyethyl methacrylate) (pHEMA)-based spongy materials possess antimicrobial properties, making them potential candidates for wound and burn dressing applications.
Investigation of the effects of bioinspired vortex generators on aerodynamic performance of a NACA0015 airfoil
(IOP Publishing Ltd, 2025) Kaya, Fatih; Akbiyik, Hurrem
An experimental study was carried out to investigate the effects of biomimetic vortex generators (biomimetic-VGs) on the aerodynamic performance of the NACA0015 airfoil. Aerodynamic force measurements and titanium dioxide (TiO2) based flow visualization technique experiments were performed for test models at Re = 1.2 x 105. Aerodynamic force measurement experiments were carried out in the wind tunnel at angles of attack of 0 degrees-18 degrees with an increment of 1 degrees. As a result of the experiments, it was revealed that the lift coefficient (CL) increased and the drag coefficient (CD) decreased by using the seaconchshell structure as a VG for the wing model. In addition, it has been observed that biomimetic models (BMs) shifted the stall angle of the airfoil by 1 degrees. In the surface oil flow visualization experiment results, the flow structure around the NACA0015 airfoil of BMs was revealed and interpreted. Moreover, it has been revealed that the aerodynamic performance of the airfoil increases as a result of the use of BMs. It is also revealed that the seaconchshell structure, which has not been studied before in the literature and which is the subject of this study, can be used as an effective flow control device.

Güncel Gönderiler