AFB1 recognition from liver tissue via AFB1 imprinted magnetic nanoparticles

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dc.authoridBaydemir Pesint, Gozde/0000-0001-8668-8296
dc.contributor.authorErdem, Veli Ziya
dc.contributor.authorBasegmez, Hatice Imge Oktay
dc.contributor.authorPesint, Gozde Baydemir
dc.date.accessioned2025-01-06T17:43:46Z
dc.date.available2025-01-06T17:43:46Z
dc.date.issued2022
dc.description.abstractAflatoxins (AFs) are produced mainly by Aspergillus flavus and Aspergillus parasiticus and aflatoxin B1 (AFB1) is one of the most toxic aflatoxins with its carcinogenic property. AFB1 recognition from samples is very important and PHEMA based AFB1 imprinted magnetic nanoparticles (magAFB1-MIPs) were synthesized for the selective AFB1 recognition from liver tissue. The AFB1-MIPs were synthesized in different mole ratios and NIPs were synthesized for control. Characterization studies of magAFB1-MIPs and NIPs were carried out by swelling tests, surface area measurements, scanning electron microscopy and particle size analysis. The surface area was found as 117 m2/g and the size of the nanoparticles were found as 483 nm in diameter. The percentage yield of polymerization was calculated as 98 % and the template (AFB1) removal ratio from the magAFB1-MIPs was calculated as 91 %. The maximum adsorbtion capacities were calculated as 427.57 ng g-1 for magAFB1-MIPs and 44.6 ng g-1 for magNIPs. Selectivity tests showed that magAFB1-MIPs adsorb AFB1 1.74, 4.40, 2.46 times selective than that of AFB2, AFG1 and AFG2 molecules, respectively. AFB1 removal amount from AFB1 spiked liver tissue was satisfactory and recorded as 10.4 ng g-1 and 54.8 ng g-1 for 2 ng g-1 and 10 ng g-1 spiked liver tissue samples, respectively. AFB1 adsorption amount decrease was found negligible for 10 consecutive adsorption-desorption repeats in reusability study.
dc.description.sponsorshipAdana Alparslan Turkes Science and Technology University Scientific Research Projects Coordination Unit [19332008]; Nanotechnology Application and Research Laboratory in Alparslan Turkes Science and Technology University, Adana, Turkey [TR62/18URET/0032]
dc.description.sponsorshipThis study was financially supported by Adana Alparslan Turkes Science and Technology University Scientific Research Projects Coordination Unit with project number of 19332008 and performed in Nanotechnology Application and Research Laboratory in Alparslan Turkes Science and Technology University, Adana, Turkey (TR62/18URET/0032).
dc.identifier.doi10.1016/j.jchromb.2022.123453
dc.identifier.issn1570-0232
dc.identifier.issn1873-376X
dc.identifier.pmid36170786
dc.identifier.scopus2-s2.0-85140144756
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.jchromb.2022.123453
dc.identifier.urihttps://hdl.handle.net/20.500.14669/2775
dc.identifier.volume1210
dc.identifier.wosWOS:000864649700004
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Chromatography B-Analytical Technologies in The Biomedical and Life Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241211
dc.subjectMycotoxin detection
dc.subjectAflatoxin B1
dc.subjectMolecular imprinting
dc.subjectMagnetic nanoparticles
dc.titleAFB1 recognition from liver tissue via AFB1 imprinted magnetic nanoparticles
dc.typeArticle

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