Melamine exposure during the weaning period negatively affects ovarian reserve

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dc.authoridErisgin, Zuleyha/0000-0003-3523-6542
dc.contributor.authorErisgin, Zuleyha
dc.contributor.authorBarak, Mensure Zuhal
dc.contributor.authorUsta, Murat
dc.contributor.authorTekelioglu, Yavuz
dc.contributor.authorTurkoglu, Ismail
dc.contributor.authorMutlu, Hasan Serdar
dc.date.accessioned2025-01-06T17:43:33Z
dc.date.available2025-01-06T17:43:33Z
dc.date.issued2023
dc.description.abstractIn this study, it was aimed to investigate the effects of melamine exposure since the weaning period on ovarian tissue and ovarian reserve. Melamine is illegally added to milk and formula to provide high false protein positivity. Female rats (the weaning period = 21 days old, n = 18) were divided into 3 groups. 0.1 mL saline was applied to the control group by gavage for 21 days. Fifty mg/kg and seventy-five mg/kg melamine was dissolved in 0.1 mL of saline and applied by gavage for 21 days, respectively. At the end of the experiment, plasma anti-Mullerian hormone (AMH) was measured, follicle count and ovarian diameter measurement were performed in the right ovaries, and flow cytometric analysis for apoptosis was performed in the left ovaries. While a statistically significant decrease was not observed in the number of the follicle and ovarian diameter between the control and melamine-treated groups (p > 0.05), a significant decrease in the corpus luteum and a significant increase in the number of atretic follicles were observed (p < 0.05). Apoptosis (Annexin V) increased in both melamine groups and AMH plasma level decreased significantly in the 75 mg/kg group (p < 0.05). Melamine exposure from the weaning (early postnatal) period may cause a decrease in ovarian reserve in parallel with a dose increase.
dc.description.sponsorshipGiresun University Scientific Research Office [SAG-BAP-A-250221-38]
dc.description.sponsorshipThis study was supported by Giresun University Scientific Research Office (Project Number: SAG-BAP-A-250221-38)
dc.identifier.doi10.1007/s11356-023-29752-7
dc.identifier.issn0944-1344
dc.identifier.issn1614-7499
dc.identifier.pmid37707728
dc.identifier.scopus2-s2.0-85171266228
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1007/s11356-023-29752-7
dc.identifier.urihttps://hdl.handle.net/20.500.14669/2712
dc.identifier.wosWOS:001068098100006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Heidelberg
dc.relation.ispartofEnvironmental Science and Pollution Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241211
dc.subjectMelamine
dc.subjectOvarian follicle
dc.subjectAnti-Mullerian hormone
dc.subjectApoptosis
dc.subjectFlow cytometry
dc.subjectWeaning period
dc.subjectRat
dc.titleMelamine exposure during the weaning period negatively affects ovarian reserve
dc.typeArticle

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