Differentially expressed Secretoglobin 1C1 gene in nasal polyposis

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dc.authoridOZDAS, Sibel/0000-0003-4610-2785
dc.contributor.authorOzdas, Sibel
dc.contributor.authorOzdas, Talih
dc.date.accessioned2025-01-06T17:43:46Z
dc.date.available2025-01-06T17:43:46Z
dc.date.issued2018
dc.description.abstractNasal polyps (NP) are the most common pathological change that occurs in the nasal mucosa and is characterized by mucosal inflammation. Although its etiology and pathogenesis have not been clearly explained, its pathophysiology is arranged by the balance between pro-inflammatory and anti-inflammatory cytokines. The Secretoglobin 1C1 gene synthesizes odor molecule binding proteins (OBPs) in the nasal mucosa and regulates some cytokines. The Secretoglobin 1C1 gene expression could be disrupted by polymorphisms that may act as a possible cause of a disruption in the regulation of the promotor of the gene. Therefore, the main aim of this study was to determine the effects of Secretoglobin 1C1 gene promotor polymorphisms on the gene expression in NP. In this study, to determine the relationship between the Secretoglobin 1C1 gene promotor polymorphisms and the gene expression, the levels of 48 subjects were sequenced (24 patients with NP and 22 controls without sinonasal disease). The levels' expression of Secretoglobin 1C1 in the subjects' nasal mucosa was also detected using RT-PCR. In this study, the level of Secretoglobin 1C1's expression increased in NP (P=0.003). Three polymorphisms were detected in the Secretoglobin 1C1 gene's promotor. The rs113795008 and rs2280540 variations were significantly high in NP (P=0.005, P=0.045). The the rs113795008 homozygous mutant type genotype (G/G) was associated with a high mRNA expression level of Secretoglobin 1C1 in NP (P=0.009). A correlation was found between a high level of Secretoglobin 1C1 expression and its promotor polymorphism, which thus might increase and/or contribute to the susceptibility of developing NP in the Turkish population. These findings suggested that promotor variations in the function of the Secretoglobin 1C1 gene can alter the gene expression biology in NP.
dc.identifier.doi10.14715/cmb/2018.64.1.17
dc.identifier.endpage102
dc.identifier.issn0145-5680
dc.identifier.issn1165-158X
dc.identifier.issue1
dc.identifier.pmid29412801
dc.identifier.scopus2-s2.0-85041722612
dc.identifier.scopusqualityQ4
dc.identifier.startpage97
dc.identifier.urihttps://doi.org/10.14715/cmb/2018.64.1.17
dc.identifier.urihttps://hdl.handle.net/20.500.14669/2788
dc.identifier.volume64
dc.identifier.wosWOS:000425228400016
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherC M B Assoc
dc.relation.ispartofCellular and Molecular Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241211
dc.subjectNasal polyps (NP)
dc.subjectSecretoglobin 1C1 gene
dc.subjectReal-Time PCR
dc.subjectSingle nucleotide polymorphisms
dc.titleDifferentially expressed Secretoglobin 1C1 gene in nasal polyposis
dc.typeArticle

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