Effects of Copper Oxide Nanoparticles on Immune and Metabolic Parameters of Galleria mellonella L

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dc.authoridTuncsoy, Benay/0000-0003-4361-3475
dc.authoridSUGECTI, SERKAN/0000-0003-3412-2367
dc.contributor.authorTuncsoy, Benay
dc.contributor.authorSugecti, Serkan
dc.contributor.authorBuyukguzel, Ender
dc.contributor.authorOzalp, Pinar
dc.contributor.authorBuyukguzel, Kemal
dc.date.accessioned2025-01-06T17:43:46Z
dc.date.available2025-01-06T17:43:46Z
dc.date.issued2021
dc.description.abstractIn this study, the effects of dietary CuO nanoparticles (NPs) on metabolic enzyme activity, biochemical parameters, and total (THC) and differential hemocyte counts (DHC) were determined in Galleria mellonella larvae. Using concentrations of 10, 100, 1000 mg/L and the LC10 and LC30 levels of CuO NPs, we determined that the NPs negatively impacted metabolic enzyme activity and biochemical parameters in larval hemolymph. Compared with the control, the greatest increase in THC was observed in larvae fed on diets with 100 mg L-1 of CuO NPs. Plasmatocytes and granulocytes were among the most numerous hemocytes in all treatments. These results suggest that dietary CuO NPs effects the metabolic metabolism and immune system of G. mellonella and provide indirect information regarding the toxic effects of CuO NPs in mammalian immune system given similarities between mammalian blood cells and insect hemocytes.
dc.identifier.doi10.1007/s00128-021-03261-0
dc.identifier.endpage420
dc.identifier.issn0007-4861
dc.identifier.issn1432-0800
dc.identifier.issue3
dc.identifier.pmid34002248
dc.identifier.scopus2-s2.0-85106250746
dc.identifier.scopusqualityQ2
dc.identifier.startpage412
dc.identifier.urihttps://doi.org/10.1007/s00128-021-03261-0
dc.identifier.urihttps://hdl.handle.net/20.500.14669/2786
dc.identifier.volume107
dc.identifier.wosWOS:000651330400001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofBulletin of Environmental Contamination and Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241211
dc.subjectNanoparticles
dc.subjectTransferase enzyme
dc.subjectHemocyte
dc.subjectGalleria mellonella
dc.titleEffects of Copper Oxide Nanoparticles on Immune and Metabolic Parameters of Galleria mellonella L
dc.typeArticle

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