Investigation of the Cortical Activity During Episodic Future Thinking in Schizophrenia: A Functional Near-Infrared Spectroscopy Study

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dc.authoridKir, Yagmur/0000-0002-4234-1394
dc.authoridBASKAK, BORA/0000-0002-0723-4446
dc.authoridGUNDUZ, Hasan/0000-0002-5495-5844
dc.authoridBARAN, ZEYNEL/0000-0001-7088-4241
dc.contributor.authorGunduz, H.
dc.contributor.authorBaran, Z.
dc.contributor.authorKir, Y.
dc.contributor.authorBaskak, N. Sedes
dc.contributor.authorBaskak, B.
dc.date.accessioned2025-01-06T17:37:45Z
dc.date.available2025-01-06T17:37:45Z
dc.date.issued2020
dc.description.abstractEpisodic future thinking (EFD refers to mental simulation of possible future events, a process that mostly depends on episodic memory (EM). EFT impairment in schizophrenia was proposed to disturb continuity in self-functioning. Schizophrenia patients are also impaired in EM as well as executive functions (EFs). In the present study, we aimed to clarify the relationship between EFT and memory functions in schizophrenia by assessing (a) whether a group of individuals with schizophrenia (schizophrenia group [SG]) who have relatively intact long-term memory functions differ from healthy controls (control group [CG]) in terms of EFT performance, and (b) whether such difference is biologically represented in terms of cortical activity. We also aimed to clarify the role of EFs in EFT in 3 task conditions: past remembering with a single cue (PR), future imagination with a single cue (FI-1C), and future imagination with 3 given cues (FI-3C). Cortical activity was monitored by functional near-infrared spectroscopy. Although the two groups showed a comparable performance in the PR, the SG performed worse than the CG in the two future-imagination conditions. In the CG, mental flexibility predicted EFT, and EM predicted PR. No such relationship was observed in the SG. In the CG only, activity was higher in the FI-1C than the PR in the middle and superior temporal cortices. In the SG, activity in the rostral prefrontal cortex (rPFC) was negatively correlated with performance in FI-3C. These results suggest that EFT is still observed but not associated with EFs in individuals with schizophrenia having relatively intact memory functions. Altered activity in the rPFC may be associated with EFT impairment in schizophrenia.
dc.identifier.doi10.1037/bne0000377
dc.identifier.endpage357
dc.identifier.issn0735-7044
dc.identifier.issn1939-0084
dc.identifier.issue4
dc.identifier.pmid32551741
dc.identifier.scopus2-s2.0-85086858820
dc.identifier.scopusqualityQ3
dc.identifier.startpage344
dc.identifier.urihttps://doi.org/10.1037/bne0000377
dc.identifier.urihttps://hdl.handle.net/20.500.14669/2335
dc.identifier.volume134
dc.identifier.wosWOS:000548597400006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAmer Psychological Assoc
dc.relation.ispartofBehavioral Neuroscience
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241211
dc.subjectepisodic future thinking
dc.subjectschizophrenia
dc.subjectexecutive functions
dc.subjectfuture imagination
dc.subjectepisodic memory
dc.titleInvestigation of the Cortical Activity During Episodic Future Thinking in Schizophrenia: A Functional Near-Infrared Spectroscopy Study
dc.typeArticle

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