Association of Ugrp2 gene polymorphisms with adenoid hypertrophy in the pediatric population

dc.authoridOz, Isilay/0000-0002-7380-4566
dc.authoridOZDAS, Sibel/0000-0003-4610-2785
dc.contributor.authorAtilla, Mahmut Hunturk
dc.contributor.authorOzdas, Sibel
dc.contributor.authorOzdas, Talih
dc.contributor.authorBastimur, Sibel
dc.contributor.authorMuz, Sami Engin
dc.contributor.authorOz, Isilay
dc.contributor.authorKurt, Kenan
dc.date.accessioned2025-01-06T17:36:07Z
dc.date.available2025-01-06T17:36:07Z
dc.date.issued2018
dc.description.abstractIntroduction: Adenoid hypertrophy is a condition that presents itself as the chronic enlargement of adenoid tissues; it is frequently observed in the pediatric population. The Ugrp2 gene, a member of the secretoglobin superfamily, encodes a low-molecular weight protein that functions in the differentiation of upper airway epithelial cells. However, little is known about the association of Ugrp2 genetic variations with adenoid hypertrophy. Objective: The aim of this study is to investigate the association of single nucleotide polymorphisms in the Ugrp2 gene with adenoid hypertrophy and its related phenotypes. Methods: A total of 219 children, comprising 114 patients suffering from adenoid hypertrophy and 105 healthy patients without adenoid hypertrophy, were enrolled in this study. Genotypes of the Ugrp2 gene were determined by DNA sequencing. Results: We identified four single nucleotide polymorphisms (IVS1-189G>A, IVS1-89T>G, c.201delC, and IVS2-15G>A) in the Ugrp2 gene. Our genotype analysis showed that the Ugrp2 (IVS1-89T>G) TG and (c.201delC) CdelC genotypes and their minor alleles were associated with a considerable increase in the risk of adenoid hypertrophy compared with the controls (p = 0.012, p = 0.009, p = 0.013, and p = 0.037, respectively). Furthermore, Ugrp2 (GTdelCG, GTdelCA) haplotypes were significantly associated with adenoid hypertrophy (four single nucleotide polymorphisms ordered from 5' to 3'; p = 0.0001). Polymorfism-Polymorfism interaction analysis indicated a strong interaction between combined genotypes of the Ugrp2 gene contributing to adenoid hypertrophy, as well as an increased chance of its diagnosis (p < 0.0001). In addition, diplotypes carrying the mutant Ugrp2 (c.201delC) allele were strongly associated with an increased risk of adenoid hypertrophy with asthma and with allergies (p = 0.003 and p = 0.0007, respectively). Conclusion: Some single nucleotide polymorphisms and their combinations in the Ugrp2 gene are associated with an increased risk of developing adenoid hypertrophy. Therefore, we tried to underline the importance of genetic factors associated with adenoid hypertrophy and its related clinical phenotypes. (C) 2017 Associacao Brasileira de Otorrinolaringologia e Cirurgia C ervico-Facial. Published by Elsevier Editora Ltda.
dc.description.sponsorshipHacettepe University Scientific Research Project Coordination Unit [2012-898]
dc.description.sponsorshipThis work was approved by the Hacettepe University Ethics Committee and financially supported by the Hacettepe University Scientific Research Project Coordination Unit (Project no 2012-898). There was no involvement in the design or conduct of the study; collection, management, analysis, or interpretation of the data; or preparation, review, or approval of the manuscript.
dc.identifier.doi10.1016/j.bjorl.2017.07.004
dc.identifier.endpage607
dc.identifier.issn1808-8694
dc.identifier.issn1808-8686
dc.identifier.issue5
dc.identifier.pmid28823693
dc.identifier.scopus2-s2.0-85027400949
dc.identifier.scopusqualityQ2
dc.identifier.startpage599
dc.identifier.urihttps://doi.org/10.1016/j.bjorl.2017.07.004
dc.identifier.urihttps://hdl.handle.net/20.500.14669/1764
dc.identifier.volume84
dc.identifier.wosWOS:000446305300011
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAssoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial
dc.relation.ispartofBrazilian Journal of Otorhinolaryngology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241211
dc.subjectAdenoid hypertrophy
dc.subjectAsthma
dc.subjectAllergy
dc.subjectUgrp2
dc.subjectSingle nucleotide polymorphism
dc.titleAssociation of Ugrp2 gene polymorphisms with adenoid hypertrophy in the pediatric population
dc.title.alternativeAssociação de polimorfismos do gene Ugrp2 com hipertrofia de adenoide na população pediátrica
dc.typeArticle

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