Antimicrobial topical polymeric films loaded with Acetyl-11-keto-?-boswellic acid (AKBA), boswellic acid and silver nanoparticles: Optimization, characterization, and biological activity

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dc.authoridAydemir, Levent Yurdaer/0000-0003-0372-1172
dc.authoridJawad, Muhammad/0009-0009-8281-4756
dc.contributor.authorJawad, Muhammad
dc.contributor.authorBhatia, Saurabh
dc.contributor.authorAl-Harrasi, Ahmed
dc.contributor.authorUllah, Sana
dc.contributor.authorHalim, Sobia Ahsan
dc.contributor.authorKhan, Ajmal
dc.contributor.authorKoca, Esra
dc.date.accessioned2025-01-06T17:36:04Z
dc.date.available2025-01-06T17:36:04Z
dc.date.issued2024
dc.description.abstractThe study examined the antimicrobial and antioxidant potential of pure Acetyl-11-keto-beta-boswellic acid (AKBA), boswellic acid (70%) and AKBA loaded nanoparticles as topical polymeric films. The optimized concentration (0.05 % w/v) of pure AKBA, boswellic acid (BA), and AKBA loaded silver nanoparticles were used to study its impact on film characteristics. Carboxymethyl cellulose (CMC), sodium alginate (SA), and gelatin (Ge) composite films were prepared in this study. The polymeric films were evaluated for their biological (antioxidant and antimicrobial activities) and mechanical characteristics such as tensile strength (TS) and elongation (%). Moreover, other parameters including water barrier properties and color attributes of the film were also evaluated. Furthermore, assessments were conducted using analytical techniques like FTIR, XRD, and SEM. Surface analysis revealed that AgNP precipitation led to a few particles in the film structure. Overall, the results indicate a relatively consistent microstructure. Moreover, due to the addition of AKBA, BA, and AgNPs, a significant decrease in TS, moisture content, water solubility, and water vapor permeation was observed. The films transparency also showed a decreasing trend, and the color analysis revealed decreasing yellowness (b*) of the films. Importantly, a significant increase in antioxidant activity against DPPH free radicals and ABTS cations was observed in the CSG films. Additionally, the AgNP-AKBA loaded films displayed significant antifungal activity against C. albicans. Moreover, the molecular docking analysis revealed the inter-molecular interactions between the AKBA, AgNPs, and composite films. The docking results indicate good binding of AKBA and silver nanoparticles with gelatin and carboxymethyl cellulosemolecules. In conclusion, these polymeric films have potential as novel materials with significant antioxidant and antifungal activities.
dc.description.sponsorshipTRC grant [BFP/RGP/HSS/22/007]
dc.description.sponsorshipThe study was supported by TRC grant number BFP/RGP/HSS/22/007.
dc.identifier.doi10.1016/j.heliyon.2024.e31671
dc.identifier.issn2405-8440
dc.identifier.issue11
dc.identifier.pmid38882278
dc.identifier.scopus2-s2.0-85194753507
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.heliyon.2024.e31671
dc.identifier.urihttps://hdl.handle.net/20.500.14669/1735
dc.identifier.volume10
dc.identifier.wosWOS:001250705800001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherCell Press
dc.relation.ispartofHeliyon
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241211
dc.subjectAcetyl-11-keto
dc.subjectbeta-boswellic acid (AKBA)
dc.subjectSilver nanoparticles (AgNPs)
dc.subjectCarboxymethyl cellulose
dc.subjectSodium alginate
dc.subjectGelatin
dc.subjectAntifungal films
dc.titleAntimicrobial topical polymeric films loaded with Acetyl-11-keto-?-boswellic acid (AKBA), boswellic acid and silver nanoparticles: Optimization, characterization, and biological activity
dc.typeArticle

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