Drug Repurposing Analysis for Colorectal Cancer through Network Medicine Framework: Novel Candidate Drugs and Small Molecules

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dc.authoridUNAL, ULKU/0000-0001-8063-5599
dc.authoridGOV, ESRA/0000-0002-5256-4778
dc.contributor.authorUnal, Ulku
dc.contributor.authorGov, Esra
dc.date.accessioned2025-01-06T17:37:02Z
dc.date.available2025-01-06T17:37:02Z
dc.date.issued2023
dc.description.abstractThis study aimed to reveal the drug-repurposing candidates for colorectal cancer (CRC) via drug-repurposing methods and network biology approaches. A novel, differentially co-expressed, highly interconnected, and co-regulated prognostic gene module was identified for CRC. Based on the gene module, polyethylene glycol (PEG), gallic acid, pyrazole, cordycepin, phenothiazine, pantoprazole, cysteamine, indisulam, valinomycin, trametinib, BRD-K81473043, AZD8055, dovitinib, BRD-A17065207, and tyrphostin AG1478 presented as drugs and small molecule candidates previously studied in the CRC. Lornoxicam, suxamethonium, oprelvekin, sirukumab, levetiracetam, sulpiride, NVP-TAE684, AS605240, 480743.cdx, HDAC6 inhibitor ISOX, BRD-K03829970, and L-6307 are proposed as novel drugs and small molecule candidates for CRC.
dc.description.sponsorshipHealth Institutes of Turkey (TUSEB); [2019-TA-01/3436]
dc.description.sponsorshipU. U. was supported in the context of the Council of Higher Education (YOK) 100/2000 Doctoral Fellowship Program of Turkey. This study was supported by the Health Institutes of Turkey (TUSEB) in the context of the project 2019-TA-01/3436.
dc.identifier.doi10.1080/07357907.2023.2255672
dc.identifier.endpage733
dc.identifier.issn0735-7907
dc.identifier.issn1532-4192
dc.identifier.issue8
dc.identifier.pmid37682113
dc.identifier.scopus2-s2.0-85171652106
dc.identifier.scopusqualityQ3
dc.identifier.startpage713
dc.identifier.urihttps://doi.org/10.1080/07357907.2023.2255672
dc.identifier.urihttps://hdl.handle.net/20.500.14669/2087
dc.identifier.volume41
dc.identifier.wosWOS:001069407000001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofCancer Investigation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241211
dc.subjectColorectal cancer
dc.subjectcomputational systems biology
dc.subjectbioinformatics
dc.subjectdrug repurposing
dc.subjectcandidate drugs
dc.titleDrug Repurposing Analysis for Colorectal Cancer through Network Medicine Framework: Novel Candidate Drugs and Small Molecules
dc.typeArticle

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