Imparting of Nearly Superparamagnetic Properties to Cryogel Scaffolds With Mesoporous MNPs for Magneto-Sensitive Tissue Engineering Strategies

Basit Öğe Kaydı
dc.authoridceylan, seda/0000-0002-1088-7886
dc.authoriddemir, didem/0000-0002-2977-2077
dc.contributor.authorDemir, Didem
dc.contributor.authorUlusal, Fatma
dc.contributor.authorUlusal, Hasan
dc.contributor.authorCeylan, Seda
dc.contributor.authorDagli, Sibel
dc.contributor.authorOzdemir, Nalan
dc.contributor.authorTarakcioglu, Mehmet
dc.date.accessioned2025-01-06T17:36:57Z
dc.date.available2025-01-06T17:36:57Z
dc.date.issued2024
dc.description.abstractThis work reports the assembly of mesoporous iron oxide nanoparticles (meso-MNPs) with cryogel scaffolds composed of chitosan and gelatin. Meso-MNPs with a particle size ranging from 2 and 50 nm, a surface area of 140.52 m2 g-1, and a pore volume of 0.27 cm3 g-1 were synthesized on a porous SiO2 template in the presence of PEG 6000 followed by leaching of SiO2. Different ratios of meso-MNPs were successfully incorporated into chitosan:gelatin cryogels up to an amount equivalent to the entire amount of polymer. The morphological structure and physicochemical properties of the cryogels were directly affected by the amount of MNPs. VSM curves showed that all composite cryogels could be magnetized by applying a magnetic field. In the context of the safety of magnetic cryogel scaffolds for use in biomedicine, it is important to note that all values are below the exposure limit for static magnetic fields, and according to cytotoxicity data, scaffolds containing meso-MNPs showed nontoxicity with cell viability ranging from 150% to 275%. In addition, microbial analysis with gram-negative and gram-positive bacteria showed that the scaffolds exhibited activity against these bacteria. image
dc.description.sponsorshipThe authors would like to thank Dr. Idris Adanur for his contributions to the interpretation of the magnetic properties of MNPs. We would like to thank the Proofreading & Editing Office of the Dean for Research at Erciyes University for copyediting and proofreading service for this manuscript.
dc.identifier.doi10.1002/bip.23623
dc.identifier.issn0006-3525
dc.identifier.issn1097-0282
dc.identifier.issue6
dc.identifier.pmid39158278
dc.identifier.scopus2-s2.0-85201545371
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/bip.23623
dc.identifier.urihttps://hdl.handle.net/20.500.14669/2053
dc.identifier.volume115
dc.identifier.wosWOS:001292996000001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofBiopolymers
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241211
dc.subjectchitosan
dc.subjectcryogel
dc.subjectgelatin
dc.subjectmagnetic nanoparticle
dc.subjectscaffold
dc.subjecttissue engineering
dc.titleImparting of Nearly Superparamagnetic Properties to Cryogel Scaffolds With Mesoporous MNPs for Magneto-Sensitive Tissue Engineering Strategies
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu