Advances in the chemical and biological diversity of heterocyclic systems incorporating pyrimido[1,6-a]pyrimidine and pyrimido[1,6-c]pyrimidine scaffolds

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dc.authoridDogru Mert, Basak/0000-0002-2270-9032
dc.contributor.authorElattar, Khaled M.
dc.contributor.authorMert, Basak Dogru
dc.contributor.authorMonier, M.
dc.contributor.authorEl-Mekabaty, Ahmed
dc.date.accessioned2025-01-06T17:44:56Z
dc.date.available2025-01-06T17:44:56Z
dc.date.issued2020
dc.description.abstractHeterocycles incorporating a pyrimidopyrimidine scaffold have aroused great interest from researchers in the field of medical chemistry because of their privileged biological activities; they are used as anti-bacterial, antiviral, anti-tumor, anti-allergic, antihypertensive, anticancer, and hepatoprotective agents. Therefore, the present study aims to investigate the chemistry of heterocycles incorporating pyrimido[1,6-a]pyrimidine and pyrimido[1,6-c]pyrimidine skeletons and their biological characteristics. The main sections discuss (1) the synthetic routes to obtain substituted pyrimidopyrimidines, pyrimido[1,6-a]pyrimidin-diones, pyrimidoquinazolines, tricyclic, tetracyclic, and binary systems; (2) the reactivity of the substituents attached to the pyrimidopyrimidine skeleton, including thione and amide groups, nucleophilic substitutions, condensations, ring transformations, and coordination chemistry; (3) compounds of this class of heterocycles containing a significant characteristic scaffold and possessing a wide range of biological characteristics.
dc.identifier.doi10.1039/d0ra00411a
dc.identifier.endpage15492
dc.identifier.issn2046-2069
dc.identifier.issue26
dc.identifier.pmid35558641
dc.identifier.scopus2-s2.0-85084058501
dc.identifier.scopusqualityQ1
dc.identifier.startpage15461
dc.identifier.urihttps://doi.org/10.1039/d0ra00411a
dc.identifier.urihttps://hdl.handle.net/20.500.14669/3253
dc.identifier.volume10
dc.identifier.wosWOS:000530037900047
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherRoyal Soc Chemistry
dc.relation.ispartofRsc Advances
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241211
dc.subjectEndothelıal Growth-Factor
dc.subjectPyrımıdıne-Derıvatıves
dc.subjectCondensed Heterocycles
dc.subjectInhıbıtors
dc.subjectChemıstry
dc.subjectQuınazolınes
dc.subjectDesıgn
dc.subjectPotent
dc.subjectCyclızatıon
dc.subjectAntagonısts
dc.titleAdvances in the chemical and biological diversity of heterocyclic systems incorporating pyrimido[1,6-a]pyrimidine and pyrimido[1,6-c]pyrimidine scaffolds
dc.typeReview Article

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