Multiomics Analysis of Tumor Microenvironment Reveals Gata2 and miRNA-124-3p as Potential Novel Biomarkers in Ovarian Cancer

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dc.authoridArga, Kazim Yalcin/0000-0002-6036-1348
dc.authoridKori, Medi/0000-0002-4589-930X
dc.contributor.authorGov, Esra
dc.contributor.authorKori, Medi
dc.contributor.authorArga, Kazim Yalcin
dc.date.accessioned2025-01-06T17:43:45Z
dc.date.available2025-01-06T17:43:45Z
dc.date.issued2017
dc.description.abstractOvarian cancer is a common and, yet, one of the most deadly human cancers due to its insidious onset and the current lack of robust early diagnostic tests. Tumors are complex tissues comprised of not only malignant cells but also genetically stable stromal cells. Understanding the molecular mechanisms behind epithelial-stromal crosstalk in ovarian cancer is a great challenge in particular. In the present study, we performed comparative analyses of transcriptome data from laser microdissected epithelial, stromal, and ovarian tumor tissues, and identified common and tissue-specific reporter biomoleculesgenes, receptors, membrane proteins, transcription factors (TFs), microRNAs (miRNAs), and metabolitesby integration of transcriptome data with genome-scale biomolecular networks. Tissue-specific response maps included common differentially expressed genes (DEGs) and reporter biomolecules were reconstructed and topological analyses were performed. We found that CDK2, EP300, and SRC as receptor-related functions or membrane proteins; Ets1, Ar, Gata2, and Foxp3 as TFs; and miR-16-5p and miR-124-3p as putative biomarkers and warrant further validation research. In addition, we report in this study that Gata2 and miR-124-3p are potential novel reporter biomolecules for ovarian cancer. The study of tissue-specific reporter biomolecules in epithelial cells, stroma, and tumor tissues as exemplified in the present study offers promise in biomarker discovery and diagnostics innovation for common complex human diseases such as ovarian cancer.
dc.description.sponsorshipMarmara University Scientific Research Projects Committee (BAPKO) [FEN-C-DRP-110915-0445]
dc.description.sponsorshipSupport by Marmara University Scientific Research Projects Committee (BAPKO) in the context of the project FEN-C-DRP-110915-0445.
dc.identifier.doi10.1089/omi.2017.0115
dc.identifier.endpage615
dc.identifier.issn1536-2310
dc.identifier.issn1557-8100
dc.identifier.issue10
dc.identifier.pmid28937943
dc.identifier.scopus2-s2.0-85032862896
dc.identifier.scopusqualityQ2
dc.identifier.startpage603
dc.identifier.urihttps://doi.org/10.1089/omi.2017.0115
dc.identifier.urihttps://hdl.handle.net/20.500.14669/2768
dc.identifier.volume21
dc.identifier.wosWOS:000413279200005
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMary Ann Liebert, Inc
dc.relation.ispartofOmics-A Journal of Integrative Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241211
dc.subjectmultiomics
dc.subjectovarian cancer
dc.subjecttumor microenvironment
dc.subjecttranscriptome
dc.subjectnetwork medicine
dc.titleMultiomics Analysis of Tumor Microenvironment Reveals Gata2 and miRNA-124-3p as Potential Novel Biomarkers in Ovarian Cancer
dc.typeArticle

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