A new application of avocado oil to enrich the biological activities of polycaprolactone membranes for tissue engineering

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dc.authoriddemir, didem/0000-0002-2977-2077
dc.authoridceylan, seda/0000-0002-1088-7886
dc.contributor.authorYurtsever, Merve Capkin
dc.contributor.authorAydogan, Selin
dc.contributor.authorIyigundogdu, Zeynep
dc.contributor.authorComertpay, Alican
dc.contributor.authorDemir, Didem
dc.contributor.authorCeylan, Seda
dc.date.accessioned2025-01-06T17:36:23Z
dc.date.available2025-01-06T17:36:23Z
dc.date.issued2024
dc.description.abstractThe metabolites synthesized by plants to protect themselves serves as natural antimicrobial agents used in biomaterials. In this study, avocado oil (AO), was incorporated as a plant source and natural antimicrobial agent into polycaprolactone (PCL) membranes. The effects of varying AO ratios (25, 50, and 100 wt%.-PCL@25AO, PCL@50AO, PCL@100AO) on PCL membrane morphology, chemical structure, wettability, antimicrobial activity, and cell viabilities were investigated. It was demonstrated that the AO acts as a pore-forming agent in solvent-casted membranes. Young's modulus of the membranes varied between 602.68 and 31.92 MPa and more flexible membranes were obtained with increasing AO content. Inhibition zones of AO were recorded between 7.86 and 13.97 mm against clinically relevant microbial strains including bacteria, yeast, and fungi. Antimicrobial activity of AO was retained in PCL membranes at all ratios. Resazurin assay indicated that PCL@25AO membranes were cytocompatible with mouse fibroblast cells (L929 cell line) on day 6 showing 72.4% cell viability with respect to neat PCL membranes. Viability results were supported by scanning electron microscopy images and DAPI staining. The overall results of this study highlight the potential of PCL@25AO membranes as a biomaterial with antimicrobial properties, cytocompatibility, and mechanical strength suitable for various biomedical applications. image
dc.description.sponsorshipThe Scientific and Technological Research Council of Tuerkiye [TUBITAK 2209A/1919B012003953]
dc.description.sponsorshipThe authors thank to The Scientific and Technological Research Council of Tuerkiye (TUBITAK 2209A/1919B012003953) for the funding.
dc.identifier.doi10.1002/bip.23617
dc.identifier.issn0006-3525
dc.identifier.issn1097-0282
dc.identifier.issue6
dc.identifier.pmid39032016
dc.identifier.scopus2-s2.0-85199026644
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/bip.23617
dc.identifier.urihttps://hdl.handle.net/20.500.14669/1850
dc.identifier.volume115
dc.identifier.wosWOS:001272310100001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofBiopolymers
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241211
dc.subjectantimicrobial activity
dc.subjectavocado oil
dc.subjectcytocompatibility
dc.subjectmembrane
dc.subjectPCL
dc.titleA new application of avocado oil to enrich the biological activities of polycaprolactone membranes for tissue engineering
dc.typeArticle

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