Determination of antimicrobial and antiviral properties of IR3535

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dc.authoridSahin, Fikrettin/0000-0003-1503-5567
dc.authoridIyigundogdu, Zeynep/0000-0003-2067-4822
dc.contributor.authorIyigundogdu, Zeynep
dc.contributor.authorKalayci, Sadik
dc.contributor.authorAsutay, Ayla Burcin
dc.contributor.authorSahin, Fikrettin
dc.date.accessioned2025-01-06T17:43:21Z
dc.date.available2025-01-06T17:43:21Z
dc.date.issued2019
dc.description.abstractInsect repellent is a substance directly applied to skin or clothing in order to repel flies, mosquitoes, ticks etc. IR3535 or Ethyl butylacetylaminopropionate (EBAAP) is a relatively new repellent which is classified as a biopesticide due to exceptional skin tolerance and overall safety. The repellency against various insect and ticks, and the low toxicity of IR3535 are well acknowledged. However, there has been no attempt to investigate the effects on microorganisms or viruses up to now. In the present study, antimicrobial activity was investigated based on disc diffusion and micro-well dilution assays. Disc diffusion assays revealed IR3535 displayed remarkable antimicrobial activity on the microorganisms tested. MIC results showed that the antifungal efficiency of IR3535 is higher with respect to its antibacterial and anticandidal efficiency. Moreover, antiviral test results revealed that IR3535 showed antiviral effects against Poliovirus and Adenovirus. This is the first study that reveals IR3535's antimicrobial and antiviral properties against a broad range of microorganisms and viruses. In consideration of the antimicrobial and antiviral properties, IR3535 is a promising agent that could be used to develop novel therapeutic approaches, new application areas and formulations in the future.
dc.description.sponsorshipYeditepe University
dc.description.sponsorshipThe authors thank Yeditepe University for supporting this research.
dc.identifier.doi10.1007/s11033-019-04632-x
dc.identifier.endpage1824
dc.identifier.issn0301-4851
dc.identifier.issn1573-4978
dc.identifier.issue2
dc.identifier.pmid30701459
dc.identifier.scopus2-s2.0-85064223575
dc.identifier.scopusqualityQ2
dc.identifier.startpage1819
dc.identifier.urihttps://doi.org/10.1007/s11033-019-04632-x
dc.identifier.urihttps://hdl.handle.net/20.500.14669/2632
dc.identifier.volume46
dc.identifier.wosWOS:000463996700029
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofMolecular Biology Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241211
dc.subjectIR3535
dc.subjectEthyl butylacetylaminopropionate
dc.subjectEBAAP
dc.subjectRepellent
dc.subjectAntimicrobial
dc.subjectAntiviral
dc.titleDetermination of antimicrobial and antiviral properties of IR3535
dc.typeArticle

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