The physicochemical properties and molecular docking study of plasticized amphotericin B loaded sodium alginate, carboxymethyl cellulose, and gelatin-based films

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dc.authoridPhilip, Anil/0000-0003-2960-330X
dc.authoridJawad, Muhammad/0009-0009-8281-4756
dc.authoridAydemir, Levent Yurdaer/0000-0003-0372-1172
dc.contributor.authorBhatia, Saurabh
dc.contributor.authorAl-Harrasi, Ahmed
dc.contributor.authorAlmohana, Ibrahim Hamza
dc.contributor.authorAlbayati, Mustafa Safa
dc.contributor.authorJawad, Muhammad
dc.contributor.authorShah, Yasir Abbas
dc.contributor.authorUllah, Sana
dc.date.accessioned2025-01-06T17:36:20Z
dc.date.available2025-01-06T17:36:20Z
dc.date.issued2024
dc.description.abstractPlasticizers are employed to stabilize films by safeguarding their physical stability and avoiding the degradation of the loaded therapeutic drug during processing and storage. In the present study, the plasticizer effect (glycerol) was studied on bioadhesive films based on sodium alginate (SA), carboxymethyl cellulose (CMC) and gelatin (GE) polymers loaded with amphotericin B (AmB). The main objective of the current study was to assess the morphological, mechanical, thermal, optical, and barrier properties of the films as a function of glycerol (Gly) concentration (0.5-1.5 %) using different techniques such as Scanning Electron Microscope (SEM), Texture analyzer (TA), Differential Scanning Calorimeter (DSC), X -Ray Diffraction (XRD), and Fourier Transforms Infrared Spectroscopy (FTIR). The concentration increase of glycerol resulted in an increase in Water Vapor Permeability (WVP) (0.187-0.334), elongation at break (EAB) (0.88-35.48 %), thickness (0.032-0.065 mm) and moisture level (17.5-41.76 %) whereas opacity, tensile strength (TS) (16.81-0.86 MPa), and young's modulus (YM) (0.194-0.002 MPa) values decreased. Glycerol incorporation in the film -Forming solution decreased the brittleness and fragility of the films. Fourier Transform Infrared (FTIR) spectra showed that intermolecular hydrogen bonding occurred between glycerol and polymers in plasticized films compared to control films. Furthermore, molecular docking was applied to predict the binding interactions betweem AmB, CMC, gelatin, SA and glycerol, which further endorsed the stabilizing effects of glycerol in the complex formation between AmB, CMC, SA, and gelatin. The Findings of the current study demonstrated that this polymeric blend could be used to successfully prepare bioadhesive films with glycerol as a plasticizer.
dc.description.sponsorshipResearch Council, Oman [BFP/URG/HSS/22/127, BFP/RGP/HSS/22/007]
dc.description.sponsorshipThe study was supported by The Research Council, Oman grant number BFP/URG/HSS/22/127 and BFP/RGP/HSS/22/007.
dc.identifier.doi10.1016/j.heliyon.2024.e24210
dc.identifier.issn2405-8440
dc.identifier.issue2
dc.identifier.pmid38304764
dc.identifier.scopus2-s2.0-85185164529
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.heliyon.2024.e24210
dc.identifier.urihttps://hdl.handle.net/20.500.14669/1821
dc.identifier.volume10
dc.identifier.wosWOS:001175271300001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherCell Press
dc.relation.ispartofHeliyon
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241211
dc.subjectAmphotericin B
dc.subjectSodium alginate
dc.subjectGlycerol
dc.subjectCarboxymethyl cellulose
dc.subjectGelatin
dc.subjectBioadhesive films
dc.subjectTopical
dc.titleThe physicochemical properties and molecular docking study of plasticized amphotericin B loaded sodium alginate, carboxymethyl cellulose, and gelatin-based films
dc.typeArticle

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