Association of Toll-Like Receptor Polymorphisms With Nasal Polyposis

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dc.authoridKesici, Gulin/0000-0003-0409-6225
dc.authoridOZDAS, Sibel/0000-0003-4610-2785
dc.contributor.authorKesici, Gulin Gokcen
dc.contributor.authorKaytez, Kargin Selda
dc.contributor.authorOzdas, Talih
dc.contributor.authorOzdas, Sibel
dc.date.accessioned2025-01-06T17:44:36Z
dc.date.available2025-01-06T17:44:36Z
dc.date.issued2021
dc.description.abstractNasal polyposis is a disease characterized with chronic inflammation of the nasal mucosa. Toll-like receptors (TLRs) are defined as essential receptors of the innate immune system and may play in the development of nasal polyposis. A total of 71 patients with nasal polyposis and 74 healthy controls were included in this study. Three single-nucleotide polymorphisms (SNPs); TLR2 (2258 A>G), TLR4 (896 A>G), and TLR4 (1196 C>T) were analyzed in all patients. The degree of pair-wise linkage disequilibrium and the genotype and haplotype analyses were conducted using regression in this logistic model and the Multifactor Dimensionality Reduction (MDR) software package was used to construct all possible interactions among different genotype variants belonging to the TLR gene. There was significant difference in genotype and allele frequencies of the TLR4 (1196 C>T) polymorphism between the nasal polyposis and control groups (0.017). Also, it was observed that the probability of nasal polyposis was 62.7% in the presence of TLR4 (1196 C>T) polymorphism with asthma (P= .007). As a conclusion, this study showed that TLR4 and TLR2 polymorphisms were predisposing factors for nasal polyposis. Further functional studies investigating the consequences of loss of TLR function are needed.
dc.identifier.doi10.1177/0145561319859305
dc.identifier.endpageNP32
dc.identifier.issn0145-5613
dc.identifier.issn1942-7522
dc.identifier.issue1
dc.identifier.pmid31304782
dc.identifier.scopus2-s2.0-85070278909
dc.identifier.scopusqualityQ2
dc.identifier.startpageNP26
dc.identifier.urihttps://doi.org/10.1177/0145561319859305
dc.identifier.urihttps://hdl.handle.net/20.500.14669/3119
dc.identifier.volume100
dc.identifier.wosWOS:000581713700001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Inc
dc.relation.ispartofEnt-Ear Nose & Throat Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241211
dc.subjectToll-like receptor
dc.subjectsingle-nucleotide polymorphism
dc.subjectnasal mucosa
dc.subjectnasal polyposis
dc.titleAssociation of Toll-Like Receptor Polymorphisms With Nasal Polyposis
dc.typeArticle

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