Effect of sainfoin (Onobrychis viciifolia Scop.) seed-based diet on rats: A comprehensive evaluation of hemogram, biochemistry, and histopathology

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dc.authoridCraine, Evan/0000-0002-6252-8973
dc.authoridsakiroglu, muhammet/0000-0002-7024-4348
dc.contributor.authorCraine, Evan B.
dc.contributor.authorMakav, Mustafa
dc.contributor.authorDag, Serpil
dc.contributor.authorYildiz, Ayfer
dc.contributor.authorEroglu, Huseyin Avni
dc.contributor.authorKuru, Buket Boga
dc.contributor.authorBektasoglu, Fikret
dc.date.accessioned2025-01-06T17:36:42Z
dc.date.available2025-01-06T17:36:42Z
dc.date.issued2024
dc.description.abstractSainfoin species (Onobrychis spp.) have been employed for centuries as an essential forage for ruminant animals, both for grazing and as hay. The seeds produced by sainfoin have also been investigated as an animal feed source and were indicated to be a particularly protein-rich supplement for monogastric animals. This study explores the effects of two sainfoin seed inclusion rates in rat diets compared to a control diet, focusing on blood biochemical parameters and a comprehensive histopathological evaluation of multiple organ systems. Thus, we provide a novel contribution to the body of evidence investigating sainfoin seeds as a protein supplement in monogastric animal diets. In this 21-day experiment, seven rats each were assigned to the control group, a 5% sainfoin seed group, and a 10% sainfoin seed group. The control group received standard feed and water; the second group received feed with 5% sainfoin seeds; and the third group received feed with 10% sainfoin seeds. At the experiment's end, necropsies and evaluations were conducted. Histopathological exams revealed normal organ structures in all 21 samples, regardless of the group. Blood analysis showed statistically significant decreases in creatine, ALT, P, Ca, and Mg levels in the sainfoin seed groups compared to the control group, with most values nearing reference levels, suggesting potential benefits. Notably, no adverse effects were observed when sainfoin seeds were included at 5% and 10% in the rat feed. These findings contribute to a growing body of research investigating the inclusion of sainfoin seeds in monogastric animal diets, which is a foundational component of assessing sainfoin's potential as a novel pulse crop for human consumption.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)
dc.description.sponsorshipNone.
dc.identifier.doi10.1002/fsn3.4117
dc.identifier.endpage4701
dc.identifier.issn2048-7177
dc.identifier.issue7
dc.identifier.pmid39055202
dc.identifier.scopus2-s2.0-85195972170
dc.identifier.scopusqualityQ1
dc.identifier.startpage4692
dc.identifier.urihttps://doi.org/10.1002/fsn3.4117
dc.identifier.urihttps://hdl.handle.net/20.500.14669/1967
dc.identifier.volume12
dc.identifier.wosWOS:001245596900001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofFood Science & Nutrition
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241211
dc.subjectblood parameters
dc.subjecthistopathology
dc.subjectPerennial Baki (TM) bean
dc.subjectrats
dc.subjectsainfoin seed
dc.titleEffect of sainfoin (Onobrychis viciifolia Scop.) seed-based diet on rats: A comprehensive evaluation of hemogram, biochemistry, and histopathology
dc.typeArticle

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