The common genetic variants of toll-like receptor and susceptibility to adenoid hypertrophy: a hospital-based cohort study

Basit Öğe Kaydı
dc.authoridOZDAS, Sibel/0000-0003-4610-2785
dc.contributor.authorBabademez, Mehmet Ali
dc.contributor.authorOzdas, Talih
dc.contributor.authorOzdas, Sibel
dc.date.accessioned2025-01-06T17:36:06Z
dc.date.available2025-01-06T17:36:06Z
dc.date.issued2016
dc.description.abstractBackground/aim: Adenoid hypertrophy (AH) is one of the most frequent pediatric disorders. The aim of this study was to investigate the effects of TLR2-R753Q, TLR4-T399I, and TLR4-D299G polymorphisms in children with AH. Materials and methods: The variants of the TLR gene were determined by restriction fragment length polymorphism (PCR-RFLP) analysis in 60 patients with AH and in 50 healthy children. Data were analyzed with SNPStats and multifactor dimensionality reduction (MDR) software. Results: We found that the presence of the G allele, the AG+GG and AG genotypes at TLR4-D299G, and the GGT haplotype were associated with AH in children (P = 0.013, P = 0.02, P = 0.038, and P = 0.001, respectively). On the contrary, no association was found between TLR2-R753Q and predisposition to AH. The CT genotype at TLR4-T399I showed a sex-specific association with AH, occurring only in boys with allergies (P = 0.0048). In addition, MDR analysis indicated a strong synergy between TLR gene markers contributing to AH. Allergic children with the diplotypes that included minor alleles of TLR4-D299G or TLR4-T399I had about a 4-fold increased risk for AH. Conclusion: Common genetic variants of the gene encoding the TLR4 protein may have differential effects on AH and the presence of sex-specific allergy.
dc.description.sponsorshipYildirim Beyazit University Scientific Research Project Coordination Unit [898]
dc.description.sponsorshipThe study protocol was approved by the Diskapi Education and Research Hospital Ethics Committee (registration number 2015-008), and financially supported by the Yildirim Beyazit University Scientific Research Project Coordination Unit (Project No: 898).
dc.identifier.doi10.3906/sag-1511-16
dc.identifier.endpage1458
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue5
dc.identifier.pmid27966312
dc.identifier.scopus2-s2.0-84995743895
dc.identifier.scopusqualityQ1
dc.identifier.startpage1449
dc.identifier.urihttps://doi.org/10.3906/sag-1511-16
dc.identifier.urihttps://hdl.handle.net/20.500.14669/1762
dc.identifier.volume46
dc.identifier.wosWOS:000389053000027
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241211
dc.subjectAdenoid hypertrophy
dc.subjectallergy
dc.subjectTLR2-R753Q
dc.subjectTLR4-D299G
dc.subjectTLR4-T399I
dc.subjectpolymorphism
dc.subjectPCR-RFLP
dc.titleThe common genetic variants of toll-like receptor and susceptibility to adenoid hypertrophy: a hospital-based cohort study
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu