Advances in the Chemistry of 6-6 Bicyclic Systems: Chemistry of Pyrido[3,4-d]pyrimidines

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dc.authoridDogru Mert, Basak/0000-0002-2270-9032
dc.contributor.authorMonier, Mohamed
dc.contributor.authorAbdel-Latif, Doaa
dc.contributor.authorEl-Mekabaty, Ahmed
dc.contributor.authorMert, Basak D.
dc.contributor.authorElattar, Khaled M.
dc.date.accessioned2025-01-06T17:44:07Z
dc.date.available2025-01-06T17:44:07Z
dc.date.issued2019
dc.description.abstractThe aim of this work is to discuss the chemistry of pyrido[3,4-d]pyrimidines as one of the most important heterocyclic compounds with remarkable synthetic, biological and medical applications. In this overview, the chemistry of hetemcyclic compounds incorporated the pyrido[3,4-d]pyrimidine scaffold as demonstrated by chemical reactions and different preparation processes. The anticipated compounds were synthesized from pyridine or pyrimidine compounds and a description of the reactivity of substituents attached to ring carbon and nitrogen atoms is discussed. On the other hand, the synthesis and reactions of fused heterocycles incorporated pyrido[3,4-d]pyrimidine scaffold is described. The diamine analogs included pyrido[3,4-d]pyrimidine core were reported as tyrosine kinase inhibitors. The chemical reactions of certain unexpected and chemically substantial compounds have been discussed.
dc.identifier.doi10.2174/1570179416666190704113647
dc.identifier.endpage854
dc.identifier.issn1570-1794
dc.identifier.issn1875-6271
dc.identifier.issue6
dc.identifier.pmid31984909
dc.identifier.scopus2-s2.0-85073961020
dc.identifier.scopusqualityQ3
dc.identifier.startpage812
dc.identifier.urihttps://doi.org/10.2174/1570179416666190704113647
dc.identifier.urihttps://hdl.handle.net/20.500.14669/2934
dc.identifier.volume16
dc.identifier.wosWOS:000499095900001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofCurrent Organic Synthesis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241211
dc.subjectPyrido[3,4-d]pyrimidines
dc.subjectsubstituents' reactivity
dc.subjectsynthetic routes
dc.subjectbiological applications
dc.subjectheterocyclic compounds
dc.subjecttyrosine kinase inhibitors
dc.titleAdvances in the Chemistry of 6-6 Bicyclic Systems: Chemistry of Pyrido[3,4-d]pyrimidines
dc.typeReview Article

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