Cholesterol imprinted composite membranes for selective cholesterol recognition from intestinal mimicking solution

Basit Öğe Kaydı
dc.authoridBaydemir Pesint, Gozde/0000-0001-8668-8296
dc.authoridErdonmez, Demet/0000-0002-5331-2206
dc.authoridAcet, Omur/0000-0003-1864-5694
dc.authoridUzun, Lokman/0000-0002-3971-7725
dc.authoridODABASI, Mehmet/0000-0002-3288-132X
dc.contributor.authorOdabasi, Mehmet
dc.contributor.authorUzun, Lokman
dc.contributor.authorBaydemir, Gozde
dc.contributor.authorAksoy, Nese Hayat
dc.contributor.authorAcet, Orntir
dc.contributor.authorErdonmez, Demet
dc.date.accessioned2025-01-06T17:43:38Z
dc.date.available2025-01-06T17:43:38Z
dc.date.issued2018
dc.description.abstractMolecularly imprinted polymers which have been extensively investigated as selective adsorbents were constructed using a template molecule during the polymerization to gain template-specific cavities. In this study, we prepared cholesterol imprinted poly(2-hydroxyethyl methacrylate-methacryloyamidotryptophan) (PHEMA-MTrp) particles embedded composite membranes. These membranes were characterized through elemental analysis, FTIR, SEM, swelling tests, and surface area measurements. Adsorption experiments were performed in a batch experimental set-up, and the adsorption medium was either a methanol or intestinal-mimicking solution. Stigmasterol and estradiol were used as competing molecules in selectivity tests. Some results are as follows: the specific surface areas of MIP particle-embedded membranes, NIP particle-embedded membranes, and membranes without particles were 36.5, 29.2 and 13.7 m(2)/g, respectively. The imprinted membranes were 1.96 and 2.13 times more selective for cholesterol when compared to stigmasterol and estradiol used as competitor agents, respectively. Cholesterol adsorption capacity increased up to 23.43 mg/g with increasing cholesterol concentration of 2 mg/mL. The MIP particle-embedded composite membranes showed a negligible loss in cholesterol adsorption capacity after ten consecutive adsorption cycles using the same adsorbent. (C) 2017 Elsevier B.V. All rights reserved.
dc.identifier.doi10.1016/j.colsurfb.2017.12.033
dc.identifier.endpage274
dc.identifier.issn0927-7765
dc.identifier.issn1873-4367
dc.identifier.pmid29316524
dc.identifier.scopus2-s2.0-85040040844
dc.identifier.scopusqualityQ1
dc.identifier.startpage266
dc.identifier.urihttps://doi.org/10.1016/j.colsurfb.2017.12.033
dc.identifier.urihttps://hdl.handle.net/20.500.14669/2752
dc.identifier.volume163
dc.identifier.wosWOS:000427217300031
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Bv
dc.relation.ispartofColloids and Surfaces B-Biointerfaces
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241211
dc.subjectMolecularly imprinted polymers (MIP)
dc.subjectParticles embedding
dc.subjectCholesterol imprinting
dc.subjectN-methacryloyl-(L)-tryptophan (MTrp)
dc.titleCholesterol imprinted composite membranes for selective cholesterol recognition from intestinal mimicking solution
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu