Targeting the tumor stroma: integrative analysis reveal GATA2 and TORYAIP1 as novel prognostic targets in breast and ovarian cancer

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dc.authoridERCEYLAN, OMER FARUK/0000-0002-4486-3583
dc.authoridGOV, ESRA/0000-0002-5256-4778
dc.contributor.authorErceylan, Omer Faruk
dc.contributor.authorSavas, Ayse
dc.contributor.authorGov, Esra
dc.date.accessioned2025-01-06T17:38:07Z
dc.date.available2025-01-06T17:38:07Z
dc.date.issued2021
dc.description.abstractTumor stroma interaction is known to take a crucial role in cancer growth and progression. In the present study, it was performed gene expression analysis of stroma samples with ovarian and breast cancer through an integrative analysis framework to identify common critical biomolecules at multiomics levels. Gene expression datasets were statistically analyzed to identify common differentially expressed genes (DEGs) by comparing tumor stroma and normal stroma samples. The integrative analyses of DEGs indicated that there were 59 common core genes, which might be feasible to be potential marks for cancer stroma targeted strategies. Reporter molecules (i.e. receptor, transcription factors and miRNAs) were determined through a statistical test employing the hypergeometric probability density function. Afterward, the tumor microenvironment protein-protein interaction and the generic network were reconstructed by using identified reporter molecules and common core DEGs. Through a systems medicine approach, it was determined that hub biomolecules, AR, GATA2, miR-124, TOR1AIP1, ESR1, EGFR, STAT1, miR-192, GATA3, COL1A1, in tumor microenvironment generic network. These molecules were also identified as prognostic signatures in breast and ovarian tumor samples via survival analysis. According to literature searching, GATA2 and TORYAIP1 might represent potential biomarkers and candidate drug targets for the stroma targeted cancer therapy applications.
dc.description.sponsorshipHealth Institutes of Turkey (TUSEB) [2019-TA-01/3436]
dc.description.sponsorshipThis work is supported by Health Institutes of Turkey (TUSEB) in the context of the project 2019-TA-01/3436.
dc.identifier.doi10.3906/biy-2010-39
dc.identifier.endpage137
dc.identifier.issn1300-0152
dc.identifier.issn1303-6092
dc.identifier.issue2
dc.identifier.pmid33907495
dc.identifier.scopus2-s2.0-85105376909
dc.identifier.scopusqualityQ1
dc.identifier.startpage127
dc.identifier.trdizinid434802
dc.identifier.urihttps://doi.org/10.3906/biy-2010-39
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/434802
dc.identifier.urihttps://hdl.handle.net/20.500.14669/2487
dc.identifier.volume45
dc.identifier.wosWOS:000642293500002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal of Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241211
dc.subjectGene expression
dc.subjectcancer stroma
dc.subjectbiomarkers
dc.subjectnetwork medicine
dc.titleTargeting the tumor stroma: integrative analysis reveal GATA2 and TORYAIP1 as novel prognostic targets in breast and ovarian cancer
dc.typeArticle

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