The Effect of Rosmarinus Officinalis and Chemotherapeutic Etoposide on Glioblastoma (U87 MG) Cell Culture

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dc.authoridOzdemir Alkis, Meryem Damla/0000-0002-5728-8004
dc.authoridGokturk, Dilek/0000-0002-1195-5828
dc.contributor.authorOzdemir, Meryem Damla
dc.contributor.authorGokturk, Dilek
dc.date.accessioned2025-01-06T17:37:46Z
dc.date.available2025-01-06T17:37:46Z
dc.date.issued2018
dc.description.abstractAIM: To investigate whether high dose toxicities of etoposide can be overcome when used in combination with a natural compound named Rosmarinus Officinalis for glioblastoma (GBM). MATERIAL and METHODS: The impact of Rosmarinus Officinalis in combination with etoposide on GBM U87 MG cells and Mouse Embryonic Fibroblast (MEF) cells was investigated. Both neutral red and 3-(4, 5-Dimethylthiazol-2-Yl)-2, 5-Diphenyltetrazolium Bromide (MTT) assays were employed to gauge cell viability. RESULTS: We observed that increased quantities of Rosmarinus Officinalis induced MEF cell proliferation while it inhibited the survival of GBM cells. Our results indicate that Rosmarinus Officinalis did not affect the cytotoxicity of etoposide on GBM cell cultures. In contrast, in the MEF cell cultures, Rosmarinus Officinalis induced proliferation and diminished the impact of etoposide. CONCLUSION: Rosmarinus Officinalis offers hope for developing new cancer treatment strategies. However, further studies are needed to verify these results.
dc.identifier.doi10.5137/1019-5149.JTN.20401-17.3
dc.identifier.endpage857
dc.identifier.issn1019-5149
dc.identifier.issue6
dc.identifier.pmid29165747
dc.identifier.scopus2-s2.0-85057187932
dc.identifier.scopusqualityQ3
dc.identifier.startpage853
dc.identifier.trdizinid299614
dc.identifier.urihttps://doi.org/10.5137/1019-5149.JTN.20401-17.3
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/299614
dc.identifier.urihttps://hdl.handle.net/20.500.14669/2344
dc.identifier.volume28
dc.identifier.wosWOS:000450653000001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Neurosurgical Soc
dc.relation.ispartofTurkish Neurosurgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241211
dc.subjectEtoposide
dc.subjectGlioblastoma
dc.subjectRosmarinus Officinalis
dc.subject487 MG cell line
dc.titleThe Effect of Rosmarinus Officinalis and Chemotherapeutic Etoposide on Glioblastoma (U87 MG) Cell Culture
dc.typeArticle

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