Ecotoxicological effects of dietary titanium dioxide nanoparticles on metabolic and biochemical parameters of model organism Galleria mellonella (Lepidoptera: Pyralidae)

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dc.authoridTuncsoy, Benay/0000-0003-4361-3475
dc.authoridBuyukguzel, Kemal/0000-0002-6959-8480
dc.contributor.authorSugecti, Serkan
dc.contributor.authorTuncsoy, Benay
dc.contributor.authorBuyukguzel, Ender
dc.contributor.authorOzalp, Pinar
dc.contributor.authorBuyukguzel, Kemal
dc.date.accessioned2025-01-06T17:43:46Z
dc.date.available2025-01-06T17:43:46Z
dc.date.issued2021
dc.description.abstractNanoparticles (NPs) are now being used in many industrial activities, such as mining, paint and glass industries. The frequent industrial use of NPs contributes to environmental pollution and may cause cellular and oxidative damage in native organisms. In this study, the toxic effects of titanium dioxide nanoparticles (TiO2 NPs) were investigated using Galleria mellonella larvae as a model insect species. Alterations in cell damage indicators, such as alanine transferase, aspartate transferase, lactate dehydrogenase, non-enzymatic antioxidants and biochemical parameters, were determined in the hemolymph of G. mellonella larvae exposed to TiO2 NPs at different concentrations (5, 50, 250 and 1250 mu g/mL) in their diets. TiO2 NPs caused concentration-dependent cellular damage in the hemolymph of G. mellonella larvae and increased the levels of the non-enzymatic antioxidants uric acid and bilirubin. In addition, total protein in hemolymph significantly decreased at the highest concentration (1250 mu g/mL) of TiO2 NPs. Level of the urea increased at the highest concentration (1250 mu g/mL) of TiO2 NPs, whereas the amount of glucose was not affected. These findings demonstrated that TiO2 NPs caused concentration-dependent toxic effects on G. mellonella larvae.
dc.identifier.doi10.1080/26896583.2021.1969846
dc.identifier.endpage434
dc.identifier.issn2689-6583
dc.identifier.issn2689-6591
dc.identifier.issue4
dc.identifier.pmid35895947
dc.identifier.scopus2-s2.0-85114651866
dc.identifier.scopusqualityQ3
dc.identifier.startpage423
dc.identifier.urihttps://doi.org/10.1080/26896583.2021.1969846
dc.identifier.urihttps://hdl.handle.net/20.500.14669/2784
dc.identifier.volume39
dc.identifier.wosWOS:000695618700001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofJournal of Environmental Science and Health Part C-Toxicology and Carcinogenesis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241211
dc.subjectNanoparticles
dc.subjectenvironmental pollution
dc.subjectnon-enzymatic antioxidants
dc.subjecttransferase enzymes
dc.subjectmodel organism
dc.titleEcotoxicological effects of dietary titanium dioxide nanoparticles on metabolic and biochemical parameters of model organism Galleria mellonella (Lepidoptera: Pyralidae)
dc.typeArticle

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