Effect of crosslinking methods on the structure and biocompatibility of polyvinyl alcohol/gelatin cryogels

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dc.authoridGokturk, Dilek/0000-0002-1195-5828
dc.authoridBolgen, Nimet/0000-0003-3162-0803
dc.authoridceylan, seda/0000-0002-1088-7886
dc.contributor.authorCeylan, Seda
dc.contributor.authorGokturk, Dilek
dc.contributor.authorBolgen, Nimet
dc.date.accessioned2025-01-06T17:37:17Z
dc.date.available2025-01-06T17:37:17Z
dc.date.issued2016
dc.description.abstractIn this study, polyvinyl alcohol (PVA) and gelatin based cryogels were prepared by crosslinking chemically or physically for tissue engineering applications. Different PVA/Gelatin ratios (100: 0, 90: 10, 70: 30, 50: 50) and crosslinking methods have been used to prepare cryogels; chemical and physical structure of the prepared matrices were analysed by FTIR and SEM; swelling and degradation profiles were followed. Chemical and physical crosslinking was obtained by using glutaraldehyde as crosslinker and by applying freeze thawing cycle, respectively. Gelatin concentration and crosslinking method had significant effect on the pore size, swelling ratio and degradation profiles of the cryogels. Biocompatibility of the cryogels were also investigated by MTT assay. SEM was used to investigate the cell morphology on the scaffolds. The MTT assay findings prove that physically crosslinked PVA/Gelatin scaffolds are more biocompatible and enhance more the adhesion and proliferation of mouse embryonic fibroblast cells (MEF) than chemically crosslinked PVA/Gelatin scaffolds. The overall results demonstrated that, the PVA/Gelatin cyrogels as a suitable biomaterial for tissue engineering applications and crosslinking methods affect the architecture and characteristic properties of the cryogels.
dc.description.sponsorshipScientific Research Projects Unit of Mersin University [BAP-FBE KMB 2014-1 YL]
dc.description.sponsorshipThis work was supported by the Scientific Research Projects Unit of Mersin University (BAP-FBE KMB (SC) 2014-1 YL).
dc.identifier.doi10.3233/BME-161589
dc.identifier.endpage340
dc.identifier.issn0959-2989
dc.identifier.issn1878-3619
dc.identifier.issue4
dc.identifier.pmid27689567
dc.identifier.scopus2-s2.0-84990057856
dc.identifier.scopusqualityQ4
dc.identifier.startpage327
dc.identifier.urihttps://doi.org/10.3233/BME-161589
dc.identifier.urihttps://hdl.handle.net/20.500.14669/2181
dc.identifier.volume27
dc.identifier.wosWOS:000385634800002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherIos Press
dc.relation.ispartofBio-Medical Materials and Engineering
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241211
dc.subjectCryogel
dc.subjectpolyvinyl alcohol
dc.subjectgelatin
dc.subjectscaffold
dc.subjecttissue engineering
dc.titleEffect of crosslinking methods on the structure and biocompatibility of polyvinyl alcohol/gelatin cryogels
dc.typeArticle

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