Biologically active sodium pentaborate pentahydrate and Hypericum perforatum oil loaded polyvinyl alcohol: chitosan membranes

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dc.contributor.authorOztas, Necla
dc.contributor.authorKara, Eray
dc.contributor.authorDemir, Didem
dc.contributor.authorYetkin, Derya
dc.contributor.authorCeylan, Seda
dc.contributor.authorIyiguendogdu, Zeynep
dc.date.accessioned2025-01-06T17:44:06Z
dc.date.available2025-01-06T17:44:06Z
dc.date.issued2024
dc.description.abstractIn this study, sodium pentaborate pentahydrate (NaB) and Hypericum perforatum (HP) oil were incorporated into polyvinyl alcohol (PVA) and chitosan (CH) polymer blend to obtain membranes by solution casting method. In order to see the synergistic effects of NaB and HP oil on the biological and physical properties of the membranes NaB and HP oil were incorporated into membrane matrix in different ratios. Fourier-transform infrared spectroscopy (FTIR) results showed that no significant bond formation between the bioactive components and the PVA:CH matrix. According to mechanical test results, Young's Modulus and elongation at break decreased from 426 MPa to 346 MPa and 52.23 % to 15.11 % for neat PVA:CH membranes and NaB and HP oil incorporated PVA:CH (PVA:CH@35NaB:HP) membranes, respectively. Antimicrobial activity tests have shown the membranes were over 99 % effective against Escherichia coli, Staphylococcus aureus, and Candida albicans, underlining their potential for infection control. Cytocompatibility assay performed with Human Dermal Fibroblast (HDFa) cells highlight the biocompatibility of the membranes, revealing 74.84 % cell viability after 72 h. The properties of NaB and HP oil doped PVA:CH based membranes obtained from these experiments reveal the promise of a versatile membrane for applications in wound healing, tissue engineering and other biomedical fields.
dc.description.sponsorshipTUBITAK [1919B012100868]
dc.description.sponsorshipThe authors thank to TUBITAK 2209 Research Projects (Project no:1919B012100868) for their support. This manuscript was enhanced scientifically with new experiments after poster presentation at EUTERMIS 2023.
dc.identifier.doi10.1016/j.ijbiomac.2024.132133
dc.identifier.issn0141-8130
dc.identifier.issn1879-0003
dc.identifier.pmid38719004
dc.identifier.scopus2-s2.0-85192459829
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2024.132133
dc.identifier.urihttps://hdl.handle.net/20.500.14669/2932
dc.identifier.volume269
dc.identifier.wosWOS:001240725000001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofInternational Journal of Biological Macromolecules
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241211
dc.subjectPVA
dc.subjectChitosan
dc.subjectNaB
dc.subjectHypericum perforatum
dc.subjectAntimicrobial membrane
dc.titleBiologically active sodium pentaborate pentahydrate and Hypericum perforatum oil loaded polyvinyl alcohol: chitosan membranes
dc.typeArticle

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