Heterocyclic steroids: Efficient routes for annulation of pentacyclic steroidal pyrimidines

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dc.authoridDogru Mert, Basak/0000-0002-2270-9032
dc.contributor.authorMonier, M.
dc.contributor.authorEl-Mekabaty, Ahmed
dc.contributor.authorAbdel-Latif, Doaa
dc.contributor.authorMert, Baak Dogru
dc.contributor.authorElattar, Khaled M.
dc.date.accessioned2025-01-06T17:44:33Z
dc.date.available2025-01-06T17:44:33Z
dc.date.issued2020
dc.description.abstractSteroids are components of cell membranes, signaling molecules and are a type of secondary metabolites as a result of their high impact of biological significance. The present review described the literature reports of pentacyclic steroidal pyrimidines as a type of heterocyclic steroids. The main sections included the synthesis of the investigated steroids fused at rings-A or B or D of steroid skeleton, synthesis of binary or linked-type pyrimidines, pyrimidine oxides, macromolecules and mono- or di- or hi-peptides linked-steroidal pyrimidines. Besides, the present research highlighted the biological significance of steroidal pyrimidines, in which the compounds revealed potent anticancer, antioxidant, antibacterial, and anti-Alzheimer agents. In addition, some hetero-steroids were screened for binding DNA assay and gene expression analysis. It was settled that the incorporation of pyrimidine scaffold into steroid basic skeleton is crucial for better biological results.
dc.identifier.doi10.1016/j.steroids.2019.108548
dc.identifier.issn0039-128X
dc.identifier.issn1878-5867
dc.identifier.pmid31805293
dc.identifier.scopus2-s2.0-85076310913
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.steroids.2019.108548
dc.identifier.urihttps://hdl.handle.net/20.500.14669/3067
dc.identifier.volume154
dc.identifier.wosWOS:000513293100002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofSteroids
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241211
dc.subjectSteroidal-pyrimidines
dc.subjectPentacyclic systems
dc.subjectSynthetic methods
dc.subjectReactivity
dc.subjectBiological activities
dc.titleHeterocyclic steroids: Efficient routes for annulation of pentacyclic steroidal pyrimidines
dc.typeReview Article

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