Development of antimicrobial nanocomposite scaffolds via loading CZTSe quantum dots for wound dressing applications

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dc.authoridOcakoglu, Kasim/0000-0003-2807-0425
dc.authoridOZTURK, ISMAIL/0000-0002-2669-3090
dc.authoridYurt, Fatma/0000-0002-9394-6908
dc.authoridTuncel, Ayca/0000-0003-0699-3309
dc.authoridceylan, seda/0000-0002-1088-7886
dc.contributor.authorCeylan, Seda
dc.contributor.authorSert, Buse
dc.contributor.authorYurt, Fatma
dc.contributor.authorTuncel, Ayca
dc.contributor.authorOzturk, Ismail
dc.contributor.authorDemir, Didem
dc.contributor.authorOcakoglu, Kasim
dc.date.accessioned2025-01-06T17:36:58Z
dc.date.available2025-01-06T17:36:58Z
dc.date.issued2022
dc.description.abstractThe antimicrobial properties of scaffolds designed for use in wound healing are accepted as an important factor in the healing process to accelerate the wound healing process without causing inflammation. For this purpose, chitosan-polyvinyl alcohol composite membranes loaded with Cu2ZnSnSe4 quantum dots (CZTSe QDs) as an antibacterial and cytocompatible biomaterial to regulate the wound healing process were produced. CZTSe QDs particles were synthesized under hydrothermal conditions. Polymer-based nanocomposites with different concentrations of the synthesized nanoparticles were produced by the solvent casting method. After detailed physicochemical and morphological characterizations of CZTSe QDs and composite membranes, antibacterial activities and cell viability were extensively investigated against gram-positive and gram-negative bacterial and yeast strains, and L929 mouse fibroblast cells lines, respectively. The results show that the preparation of composite scaffolds at a QDs concentration of 3.3% by weight has the best antimicrobial activity. Composite scaffold membranes, which can be obtained as a result of an easy production process, are thought to have great potential applications in tissue engineering as wound dressing material due to their high mechanical properties, wettability, strong antibacterial properties and non-toxicity.
dc.identifier.doi10.1088/1748-605X/ac943e
dc.identifier.issn1748-6041
dc.identifier.issn1748-605X
dc.identifier.issue6
dc.identifier.pmid36137521
dc.identifier.scopus2-s2.0-85139536362
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1088/1748-605X/ac943e
dc.identifier.urihttps://hdl.handle.net/20.500.14669/2057
dc.identifier.volume17
dc.identifier.wosWOS:000862120600001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherIop Publishing Ltd
dc.relation.ispartofBiomedical Materials
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241211
dc.subjectchitosan
dc.subjectPVA
dc.subjectCZTSe QDs
dc.subjectantimicrobial activity
dc.subjectcytocompatibility
dc.titleDevelopment of antimicrobial nanocomposite scaffolds via loading CZTSe quantum dots for wound dressing applications
dc.typeArticle

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