Pterostilbene suppresses head and neck cancer cell proliferation via induction of apoptosis

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dc.contributor.authorOzdas, Talih
dc.contributor.authorOzdas, Sibel
dc.contributor.authorCanatar, Ipek
dc.contributor.authorKaypak, Erdem
dc.date.accessioned2025-01-06T17:38:20Z
dc.date.available2025-01-06T17:38:20Z
dc.date.issued2024
dc.description.abstractBackground/aim: Head and neck cancer (HNC) is one of the most prevalent causes of death worldwide, and so discovering anticancer agents for its treatment is very important. Pterostilbene (PS) is a trans-stilbene reported to be beneficial in managing various cancers. The objective of the study was to evaluate the cytotoxic, antiproliferative, proapoptotic, and antimigrative effect of PS on HEp-2, SCC-90, SCC-9, FaDu, and Detroit-551 cell lines. Materials and methods: MTT and live/dead assays were employed to assess cell viability, while a cell migration test was performed to evaluate wound healing capacity. The mRNA, protein, and intracellular expression levels of CASP-3, BAX, and BCL-2 genes were evaluated by real-time PCR, western blotting, and immunofluorescence staining. Annexin V-PI staining was conducted to assess the amounts of viable, apoptotic, and necrotic cells. Results: The results revealed that PS displayed cytotoxic, antiproliferative activity in a dose-dependent manner in HNC cells by upregulating CASP-3 and BCL-2 while downregulating BCL-2 in the apoptotic pathway. The proapoptotic properties were confirmed by the annexin-V-IP results. Moreover, PS displayed a significant suppressive efficacy on the migration capacity of HNC cells. Conclusion: The present study provides proof that PS has the prospective to be improved as an attractive anticancer agent against HNC following advanced studies.
dc.description.sponsorshipHealth Institutes of Turkiye (TUSEB) [11912]; Adana Alparslan Tuerkescedil; Science and Technology University Scientific Research Projects Coordination Unit; Adana Alparslan Turkes Science and Technology University Scientific Research Projects Coordiation Unit
dc.description.sponsorshipThe study was financially supported by Health Institutes of Turkiye (TUSEB) (Project Number: 11912) and Adana Alparslan Turkes Science and Technology University Scientific Research Projects Coordination Unit (Project Number: 21103017).
dc.identifier.doi10.55730/1300-0152.2708
dc.identifier.issn1300-0152
dc.identifier.issn1303-6092
dc.identifier.issue5
dc.identifier.pmid39474042
dc.identifier.scopus2-s2.0-85207543653
dc.identifier.scopusqualityQ1
dc.identifier.trdizinid1276339
dc.identifier.urihttps://doi.org/10.55730/1300-0152.2708
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1276339
dc.identifier.urihttps://hdl.handle.net/20.500.14669/2544
dc.identifier.volume48
dc.identifier.wosWOS:001338114600005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal of Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241211
dc.subjectHead and neck cancer
dc.subjectpterostilbene
dc.subjectanticancer
dc.subjectcytotoxicity
dc.subjectapoptosis
dc.titlePterostilbene suppresses head and neck cancer cell proliferation via induction of apoptosis
dc.typeArticle

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