The concurrent effect of acyclovir and rosemary on glioblastoma cell culture

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dc.authoridGokturk, Dilek/0000-0002-1195-5828
dc.authoridOzdemir Alkis, Meryem Damla/0000-0002-5728-8004
dc.contributor.authorOzdemir, Meryem Damla
dc.contributor.authorGokturk, Dilek
dc.date.accessioned2025-01-06T17:43:16Z
dc.date.available2025-01-06T17:43:16Z
dc.date.issued2019
dc.description.abstractHuman cytomegalovirus (HCMV) is a beta herpesvirus which large amount of people in world has interacted with. Recent studies indicated that CMV DNA is associated with several cancer types including Glioblastoma (GBM) which is the most common and aggressive type of primary brain cancer. In clinical studies it was shown that several antiviral medicines prolonged life span of glioblastoma patients. One of them is Acyclovir (ACV) which is a type of nucleoside analog, used to cure viral infections and might be a potential treatment supplement for Glioblastoma. In this study we aimed to investigate if ACV had cytotoxic effect on glioblastoma cell line U87 MG and also the effect of ACV on healthy cells. Furthermore it was aimed to search the effect of Rosmarinus Officinalis also known as rosemary which is an aromatic, perennial plant concurrent with ACV on glioblastoma and healthy cells.
dc.identifier.doi10.14715/cmb/2019.65.3.9
dc.identifier.endpage71
dc.identifier.issn0145-5680
dc.identifier.issn1165-158X
dc.identifier.issue3
dc.identifier.pmid30942157
dc.identifier.scopus2-s2.0-85064210405
dc.identifier.scopusqualityQ4
dc.identifier.startpage66
dc.identifier.urihttps://doi.org/10.14715/cmb/2019.65.3.9
dc.identifier.urihttps://hdl.handle.net/20.500.14669/2576
dc.identifier.volume65
dc.identifier.wosWOS:000462736500009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherC M B Assoc
dc.relation.ispartofCellular and Molecular Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241211
dc.subjectHuman cytomegalovirus (HCMV)
dc.subjectAcyclovir (ACV)
dc.subjectGlioblastoma multiforme (GBM)
dc.subjectMouse Embryonic Fibroblast (MEF)
dc.subjectRosmarinus Officinalis
dc.titleThe concurrent effect of acyclovir and rosemary on glioblastoma cell culture
dc.typeArticle

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