Tannic acid purification from pomegranate peel via tannic acid imprinted particle-embedded cryogel column

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dc.authoridZenger, Okan/0000-0002-5669-0325
dc.contributor.authorPesint, Gozde Baydemir
dc.contributor.authorCemek, Kardelen
dc.contributor.authorZenger, Okan
dc.contributor.authorAnar, Baris Can
dc.contributor.authorBasegmez, Hatice Imge Oktay
dc.date.accessioned2025-01-06T17:44:34Z
dc.date.available2025-01-06T17:44:34Z
dc.date.issued2023
dc.description.abstractTannic acid (TA) is hydrolysable tannin found in the leaves and bark of many herbaceous and woody plants. Purification of TA is important due to its antibacterial, antihistaminic, antioxidant, antimutagenic and antitussive properties. In this study, 2-hydroxyethyl methacrylate-based TA-imprinted particle embedded cryogel (TA-MIP) was synthesized to purify TA from pomegranate peel. Furthermore, non-imprinted particle embedded cryogel (NIP) was synthesized to determine specific adsorption properties of TA-MIP, and control cryogel was synthesized without embedding procedure. The synthesized cryogel columns were characterized via scanning electron microscopy, Brunauer-Emmett-Teller surface area analysis, fourier-transform infrared spectroscopy, and swelling studies. Particle-embedding procedure resulted in a significantly higher specific surface area of particle-embedded columns (TA-MIP and NIP, 29 m(2)/g and 25 m(2)/g, respectively) than the specific surface area of control cryogel (9 m(2)/g). Adsorption studies were performed from aqueous solutions and maximum TA adsorption was found to be 34.4 mg/g for TA-MIP, 3.9 mg/g for NIP, and 2.8 mg/g for control cryogel. Within the scope of selectivity study, it was demonstrated that the synthesized columns have a high selectivity for TA against gallic acid (GA) and quercetin (QCT). Finally, purification of TA directly from pomegranate peel extract was studied and results were confirmed by HPLC. Furthermore, it has been proven that TA-MIP cryogel columns can be repeatedly used up to ten-times without any remarkable reduction in the TA adsorption amount.
dc.description.sponsorshipTUBITAK 2209-A [TR62-18-UERET/0032]; Cukurova Development Agency; [1919B012204687]
dc.description.sponsorshipThis research was supported by TUBITAK 2209-A with the project number 1919B012204687, and it was conducted at the Nanotechnology Research and Application Laboratory established at Adana Alparslan Turkes ,Science and Technology University with the financial support of Cukurova Development Agency (Contract number: TR62-18-UERET/0032) .
dc.identifier.doi10.1016/j.jchromb.2023.123890
dc.identifier.issn1570-0232
dc.identifier.issn1873-376X
dc.identifier.pmid37748351
dc.identifier.scopus2-s2.0-85171788678
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.jchromb.2023.123890
dc.identifier.urihttps://hdl.handle.net/20.500.14669/3095
dc.identifier.volume1229
dc.identifier.wosWOS:001156745200001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Chromatography B-Analytical Technologies in The Biomedical and Life Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241211
dc.subjectTannic acid
dc.subjectPurification
dc.subjectPomegranate peel
dc.subjectCryogel
dc.subjectMolecular imprinting
dc.titleTannic acid purification from pomegranate peel via tannic acid imprinted particle-embedded cryogel column
dc.typeArticle

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