Role of polygenic and environmental factors in the co-occurrence of depression and psychosis symptoms: a network analysis

Basit Öğe Kaydı
dc.authoridKonac, Deniz/0000-0002-0121-1067
dc.authoridNewbury, Joanne/0000-0002-4080-4033
dc.authoridBarker, Edward/0000-0002-9914-8958
dc.authoridGarcia Mondragon, Liliana/0000-0003-0141-6094
dc.authoridFurtjes, Anna Elisabeth/0000-0001-6590-4957
dc.contributor.authorGarcia-Mondragon, Liliana
dc.contributor.authorKonac, Deniz
dc.contributor.authorNewbury, Joanne B.
dc.contributor.authorYoung, Katherine S.
dc.contributor.authorIng, Alex
dc.contributor.authorFurtjes, Anna E.
dc.contributor.authorBarker, Edward D.
dc.date.accessioned2025-01-06T17:44:53Z
dc.date.available2025-01-06T17:44:53Z
dc.date.issued2022
dc.description.abstractDepression and psychosis are often comorbid; they also have overlapping genetic and environmental risk factors, including trauma and area-level exposures. The present study aimed to advance understanding of this comorbidity via a network approach, by (1) identifying bridge nodes that connect clusters of lifetime depression and psychosis symptoms and (2) evaluating the influence of polygenic and environmental risk factors in these symptoms. This study included data from European ancestry participants in UK Biobank, a large population-based sample (N = 77,650). In Step 1, a network model identified bridge nodes between lifetime symptoms of depression and psychosis and functional impairment. In Step 2, genetic and environmental risk factors were incorporated to examine the degree to which symptoms associated with polygenic risk scores for depression and schizophrenia, lifetime exposure to trauma and area-level factors (including deprivation, air pollution and greenspace). Feelings of worthlessness, beliefs in unreal conspiracy against oneself, depression impairment and psychosis impairment emerged as bridges between depression and psychosis symptoms. Polygenic risk scores for depression and schizophrenia were predominantly linked with depression and psychosis impairment, respectively, rather than with specific symptoms. Cumulative trauma emerged as a bridge node associating deprivation with feelings of worthlessness and beliefs in unreal conspiracy, indicating that the experience of trauma is prominently linked with the co-occurrence of depression and psychosis symptoms related to negative views of oneself and others. These key symptoms and risk factors provide insights into the lifetime co-occurrence of depression and psychosis.
dc.description.sponsorshipUK Biobank [63994]; Economic and Social Research Council [ES/R005516/1]; International Max Planck Research School of Translational Psychiatry (IMPRS-TP); ESRC [ES/R005516/1] Funding Source: UKRI
dc.description.sponsorshipThis research was conducted with the use of the UK Biobank resource, under UK Biobank project number 63994. We would like to thank the UK Biobank participants and coordinators for this dataset. This research was supported by the Economic and Social Research Council under Grant ES/R005516/1 (to EDB). LGM is supported by the International Max Planck Research School of Translational Psychiatry (IMPRS-TP).
dc.identifier.doi10.1038/s41398-022-02022-9
dc.identifier.issn2158-3188
dc.identifier.issue1
dc.identifier.pmid35732632
dc.identifier.scopus2-s2.0-85132446642
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1038/s41398-022-02022-9
dc.identifier.urihttps://hdl.handle.net/20.500.14669/3232
dc.identifier.volume12
dc.identifier.wosWOS:000814671400001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringernature
dc.relation.ispartofTranslational Psychiatry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241211
dc.subjectChıldhood Trauma
dc.subjectPosıtıve Symptoms
dc.subjectAır-Pollutıon
dc.subjectGlobal Burden
dc.subjectDısorders
dc.subjectSchızophrenıa
dc.subjectRısk
dc.subjectExperıences
dc.subjectAssocıatıon
dc.subjectDeprıvatıon
dc.titleRole of polygenic and environmental factors in the co-occurrence of depression and psychosis symptoms: a network analysis
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu