An impedimetric determination of zearalenone on MIP-modified carboceramic electrode

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dc.authoridIPEK, SEMIH LATIF/0000-0002-4661-7765
dc.authoridKucuk, Dilruba/0009-0004-4748-0838
dc.contributor.authorKucuk, Dilruba
dc.contributor.authorUner, Guelcan
dc.contributor.authorIpek, Semih Latif
dc.contributor.authorCaglayan, Mustafa Oguzhan
dc.contributor.authorUstundag, Zafer
dc.date.accessioned2025-01-06T17:44:51Z
dc.date.available2025-01-06T17:44:51Z
dc.date.issued2024
dc.description.abstractZearalenone (ZEN) is a mycotoxin that poses significant risks to human and animal health due to its mutagenic, immunosuppressive, and carcinogenic properties. This study presents a novel analytical method for detecting ZEN using electrochemical impedance spectroscopy (EIS) combined with a molecularly imprinted polymer (MIP). ZEN, used as the template molecule, was incorporated into polypyrrole on screen-printed electrodes (SPE), and a ZEN-sensitive MIP sensor was created through template removal. The modified sensor surfaces were characterized by EIS and scanning electron microscopy (SEM). An impedimetric MIP sensor for ZEN was developed, offering a detection range from 1 pM to 500 pM. The method's limit of detection (LOD) was established at 1 pM (0.3 pg/mL) with a signal-to-noise ratio of 3 (S/N = 3). The method demonstrated high precision and accuracy, with a maximum relative standard deviation (RSD) of less than 4.4% at a 95% confidence level, and relative error (RE) values ranging from -0.8% to -2.7%. The selectivity of the developed MIP sensor was evaluated using ochratoxin A, ochratoxin B, and aflatoxin B1, with no significant interference observed. ZEN recovery from spiked samples was between 95% and 105%, indicating that the method was successfully applied to grain samples, including corn, rice, and wheat.
dc.description.sponsorshipTUBITAK 2209-A- Research Project Support Program [1919B012108952]; Kutahya Dumlupinar University [2022-60]
dc.description.sponsorshipThis study was supported by the TUBITAK 2209-A-Research Project Support Program, under project number 1919B012108952. Addition-ally, the authors would like to thank Kutahya Dumlupinar University for the financial contribution to this study through the BAP project numbered 2022-60.
dc.identifier.doi10.1016/j.toxicon.2024.108115
dc.identifier.issn0041-0101
dc.identifier.issn1879-3150
dc.identifier.pmid39368557
dc.identifier.scopus2-s2.0-85205436006
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.toxicon.2024.108115
dc.identifier.urihttps://hdl.handle.net/20.500.14669/3210
dc.identifier.volume250
dc.identifier.wosWOS:001333348200001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofToxicon
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241211
dc.subjectZearalenone
dc.subjectMycotoxin
dc.subjectElectrochemical impedance spectroscopy
dc.subjectMolecularly imprinted polymer
dc.titleAn impedimetric determination of zearalenone on MIP-modified carboceramic electrode
dc.typeArticle

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