Molecularly imprinted spongy columns for Angiotensin(II) recognition from human serum

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dc.authoridBaydemir Pesint, Gozde/0000-0001-8668-8296
dc.authoridYILDIRIM, Mehtap/0000-0002-9809-875X
dc.contributor.authorYildirim, Mehtap
dc.contributor.authorPesint, Gozde Baydemir
dc.date.accessioned2025-01-06T17:36:21Z
dc.date.available2025-01-06T17:36:21Z
dc.date.issued2021
dc.description.abstractAngiotensin II (AngII), the effector peptide of the renin angiotensin system and has an important role in regulating cardiovascular hemodynamics and structure. AngII is an important biomarker for certain diseases that are associated with cardiovascular disorders, i.e., influenza, SARS-CoV-2, tumors, hypertension, etc. However, AngII presents in blood in very low concentrations and they are not stable due to their reactivity, therefore spontaneous detection of AngII is a big challenge. In this study, AngII-imprinted spongy columns (AngII-misc) synthesized for AngII detection from human serum, and characterized by surface area measurements (BET), swelling tests, scanning electron microscopy (SEM), FTIR studies. AngII binding studies were achieved from aqueous environment and maximum binding capacity was found as 0.667 mg/g. It was calculated that the AngII-miscs recognized AngII 8.27 and 14.25 times more selectively than competitor Angiotensin I and Vasopressin molecules. Newly produced AngII-misc binds 60.5 pg/g AngII from crude human serum selectively. It has a great potential for spontaneous detection of AngII from human serum for direct and critical measurements in serious diseases, that is, heart attacks, SARS-CoV-2, etc.
dc.description.sponsorshipCukurova Development Agengy/Adana Alparslan Turkes Science and Technology University/Nanotechnology Application and Research Laboratory [TR62/18URET/0032]; Scientific Research Projects Coordination Unit of Adana Alparslan Turkes Science and Technology University [19332002]
dc.description.sponsorshipCukurova Development Agengy/Adana Alparslan Turkes Science and Technology University/Nanotechnology Application and Research Laboratory, Grant/Award Number: TR62/18URET/0032; Scientific Research Projects Coordination Unit of Adana Alparslan Turkes Science and Technology University, Grant/Award Number: 19332002
dc.identifier.doi10.1002/btpr.3112
dc.identifier.issn8756-7938
dc.identifier.issn1520-6033
dc.identifier.issue2
dc.identifier.pmid33342088
dc.identifier.scopus2-s2.0-85098282999
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/btpr.3112
dc.identifier.urihttps://hdl.handle.net/20.500.14669/1834
dc.identifier.volume37
dc.identifier.wosWOS:000603435500001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofBiotechnology Progress
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241211
dc.subjectangiotensin(II)
dc.subjectcardiovascular disorders
dc.subjectCryogels
dc.subjectmolecular imprinting
dc.titleMolecularly imprinted spongy columns for Angiotensin(II) recognition from human serum
dc.typeArticle

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