Identification of Common Pathogenetic Processes between Schizophrenia and Diabetes Mellitus by Systems Biology Analysis

Basit Öğe Kaydı
dc.authoridDemirtas, Talip Yasir/0000-0003-0122-2767
dc.authoridFisicaro, Francesco/0000-0002-1579-8807
dc.authoridIslam, Md Rafiqul/0000-0002-7370-2535
dc.authoridBramanti, Alessia/0000-0002-5247-9901
dc.authoridNICOLETTI, Ferdinando/0000-0002-4570-8462
dc.authoridMoni, Mohammad Ali/0000-0003-0756-1006
dc.authoridFagone, Paolo/0000-0002-6694-1992
dc.contributor.authorRahman, Md Rezanur
dc.contributor.authorIslam, Tania
dc.contributor.authorNicoletti, Ferdinando
dc.contributor.authorPetralia, Maria Cristina
dc.contributor.authorCiurleo, Rosella
dc.contributor.authorFisicaro, Francesco
dc.contributor.authorPennisi, Manuela
dc.date.accessioned2025-01-06T17:44:18Z
dc.date.available2025-01-06T17:44:18Z
dc.date.issued2021
dc.description.abstractSchizophrenia (SCZ) is a psychiatric disorder characterized by both positive symptoms (i.e., psychosis) and negative symptoms (such as apathy, anhedonia, and poverty of speech). Epidemiological data show a high likelihood of early onset of type 2 diabetes mellitus (T2DM) in SCZ patients. However, the molecular processes that could explain the epidemiological association between SCZ and T2DM have not yet been characterized. Therefore, in the present study, we aimed to identify underlying common molecular pathogenetic processes and pathways between SCZ and T2DM. To this aim, we analyzed peripheral blood mononuclear cell (PBMC) transcriptomic data from SCZ and T2DM patients, and we detected 28 differentially expressed genes (DEGs) commonly modulated between SCZ and T2DM. Inflammatory-associated processes and membrane trafficking pathways as common biological processes were found to be in common between SCZ and T2DM. Analysis of the putative transcription factors involved in the regulation of the DEGs revealed that STAT1 (Signal Transducer and Activator of Transcription 1), RELA (v-rel reticuloendotheliosis viral oncogene homolog A (avian)), NFKB1 (Nuclear Factor Kappa B Subunit 1), and ERG (ETS-related gene) are involved in the expression of common DEGs in SCZ and T2DM. In conclusion, we provide core molecular signatures and pathways that are shared between SCZ and T2DM, which may contribute to the epidemiological association between them.
dc.description.sponsorshipIRCCS Centro Neurolesi Bonino-Pulejo, Messina, Italy
dc.description.sponsorshipThis study was supported by current research funds 2020 of IRCCS Centro Neurolesi Bonino-Pulejo, Messina, Italy.
dc.identifier.doi10.3390/genes12020237
dc.identifier.issn2073-4425
dc.identifier.issue2
dc.identifier.pmid33562405
dc.identifier.scopus2-s2.0-85100702877
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.3390/genes12020237
dc.identifier.urihttps://hdl.handle.net/20.500.14669/2987
dc.identifier.volume12
dc.identifier.wosWOS:000622556700001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofGenes
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241211
dc.subjectschizophrenia
dc.subjecttype 2 diabetes mellitus
dc.subjectdifferentially expressed genes
dc.subjectpathways
dc.subjecttranscription factors
dc.titleIdentification of Common Pathogenetic Processes between Schizophrenia and Diabetes Mellitus by Systems Biology Analysis
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu