Significant association between SCGB1D4 gene polymorphisms and susceptibility to adenoid hypertrophy in a pediatric population

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dc.authoridOZDAS, Sibel/0000-0003-4610-2785
dc.authoridOz, Isilay/0000-0002-7380-4566
dc.contributor.authorOzdas, Talih
dc.contributor.authorOzdas, Sibel
dc.contributor.authorBabademez, Mehmet Ali
dc.contributor.authorMuz, Sami Engin
dc.contributor.authorAtilla, M. Hunturk
dc.contributor.authorBastimur, Sibel
dc.contributor.authorIzbirak, Afife
dc.date.accessioned2025-01-06T17:36:06Z
dc.date.available2025-01-06T17:36:06Z
dc.date.issued2017
dc.description.abstractBackground/aim: Adenoid hypertrophy (AH) is chronic enlargement of the adenoid tissue. The pathophysiology of the disease is unclear. We analyzed SCGB1D4 gene polymorphisms in order to determine the effect of the variants or their genetic combinations on AH. Materials and methods: We genotyped the SCGB1D4 (IIS) gene in 167 participants (95 children with AH and 72 controls) by performing DNA sequencing in blood samples. Results: We genotyped three single nucleotide polymorphisms (SNPs). In the analysis, we found that in the presence of those SNPs and the minor alleles of individual SNPs four haplotypes were associated with an increased risk of AH. In addition, those SNPs were significantly associated with asthma, allergy, sleep-disordered breathing, AH grade + 4, and a high level of IgE. As indicated on multifactor dimensionality reduction analysis, single-locus (rs35328961), two-locus (rs35328961_rs56196602), and three-locus models (rs200327820_rs35328961_rs56196602) had the highest synergistic interaction effect on AH. The three-factor model was also significantly associated with some genotypes of rs35328961 and allergic-asthmatic AH. Conclusion: SNPs of SCGB1D4 and their combinations are associated with an increased risk for developing AH. We highlighted the importance of genetic factors on AH and AH-related clinical phenotypes.
dc.description.sponsorshipHacettepe University Scientific Research Project Coordination Unit [898]
dc.description.sponsorshipThis study was approved by the Hacettepe University Ethics Committee and financially supported by the Hacettepe University Scientific Research Project Coordination Unit (Project No: 898).
dc.identifier.doi10.3906/sag-1512-93
dc.identifier.endpage210
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue1
dc.identifier.pmid28263490
dc.identifier.scopus2-s2.0-85014100931
dc.identifier.scopusqualityQ1
dc.identifier.startpage201
dc.identifier.urihttps://doi.org/10.3906/sag-1512-93
dc.identifier.urihttps://hdl.handle.net/20.500.14669/1763
dc.identifier.volume47
dc.identifier.wosWOS:000395632600029
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241211
dc.subjectAdenoid hypertrophy
dc.subjectasthma
dc.subjectallergy
dc.subjectSDB
dc.subjectSNP
dc.subjectsecretoglobins
dc.subjectSCGB1D4
dc.subjectDNA sequence analysis
dc.subjectPCR
dc.subjectMDR
dc.subjecthaplotypes
dc.subjectgene
dc.titleSignificant association between SCGB1D4 gene polymorphisms and susceptibility to adenoid hypertrophy in a pediatric population
dc.typeArticle

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