Optimized Peppermint Essential Oil Microcapsules Loaded into Gelatin-Based Cryogels with Enhanced Antimicrobial Activity

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dc.authoridceylan, seda/0000-0002-1088-7886
dc.authoridGoksen, Gulden/0000-0002-5432-7936
dc.authoridTrif, Monica/0000-0001-6538-0815
dc.authoriddemir, didem/0000-0002-2977-2077
dc.authoridRusu, Alexandru/0000-0002-0026-6138
dc.contributor.authorDemir, Didem
dc.contributor.authorGoksen, Gulden
dc.contributor.authorCeylan, Seda
dc.contributor.authorTrif, Monica
dc.contributor.authorRusu, Alexandru Vasile
dc.date.accessioned2025-01-06T17:38:07Z
dc.date.available2025-01-06T17:38:07Z
dc.date.issued2023
dc.description.abstractIn this study, chitosan (Chi) was used to microencapsulate peppermint essential oil (PEO). A novel gelatin-based cryogel loaded with PEO microcapsules was further developed and characterized for potential applications. Four different cryogel systems were designed, and the morphological, molecular, physical and antibacterial properties were investigated. Additionally, the antimicrobial properties of PEO, alone and microcapsulated, incorporated into the cryogel network were evaluated. The observed gel structure of cryogels exhibited a highly porous morphology in the microcapsules. The highest values of the equilibrium swelling ratio were acquired for the GelCryo-ChiCap and GelCryo-PEO@ChiCap samples. The contact angle GelCryo-PEO@ChiCap sample was lower than the control (GelCryo) due to the water repelling of the essential oil. It has been found that the incorporation of encapsulated PEO into the cryogels would be more advantageous compared to its direct addition. Moreover, GelCryo-PEO@ChiCap cryogels showed the strongest antibacterial activities, especially against Staphylococcus aureus (Gram-positive bacteria) and Escherichia coli (Gram-negative bacteria). The system that was developed showed promising results, indicating an improved antibacterial efficacy and enhanced structural properties due to the presence of microcapsules. These findings suggest that the system may be an appropriate candidate for various applications, including, but not limited to, drug release, tissue engineering, and food packaging. Finally, this system demonstrates a strategy to stabilize the releasing of the volatile compounds for creating successful results.
dc.identifier.doi10.3390/polym15132782
dc.identifier.issn2073-4360
dc.identifier.issue13
dc.identifier.pmid37447427
dc.identifier.scopus2-s2.0-85164932249
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/polym15132782
dc.identifier.urihttps://hdl.handle.net/20.500.14669/2482
dc.identifier.volume15
dc.identifier.wosWOS:001028582600001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofPolymers
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241211
dc.subjectgelatin
dc.subjectchitosan
dc.subjectpeppermint essential oil
dc.subjectmicrocapsule
dc.subjectcryogel
dc.subjectantibacterial
dc.titleOptimized Peppermint Essential Oil Microcapsules Loaded into Gelatin-Based Cryogels with Enhanced Antimicrobial Activity
dc.typeArticle

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