Cancer Stem Cell Transcriptome Profiling Reveals Seed Genes of Tumorigenesis: New Avenues for Cancer Precision Medicine

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dc.authoridArga, Kazim Yalcin/0000-0002-6036-1348
dc.authoridGOV, ESRA/0000-0002-5256-4778
dc.contributor.authorComertpay, Betul
dc.contributor.authorGulfidan, Gizem
dc.contributor.authorArga, Kazim Yalcin
dc.contributor.authorGov, Esra
dc.date.accessioned2025-01-06T17:36:47Z
dc.date.available2025-01-06T17:36:47Z
dc.date.issued2021
dc.description.abstractCancer stem-like cells (CSCs) possess the ability to self-renew and differentiate, and they are among the major factors driving tumorigenesis, metastasis, and resistance to chemotherapy. Therefore, it is critical to understand the molecular substrates of CSC biology so as to discover novel molecular biosignatures that distinguish CSCs and tumor cells. Here, we report new findings and insights by employing four transcriptome datasets associated with CSCs, with CSC and tumor samples from breast, lung, oral, and ovarian tissues. The CSC samples were analyzed to identify differentially expressed genes between CSC and tumor phenotypes. Through comparative profiling of expression levels in different cancer types, we identified 17 seed genes that showed a mutual differential expression pattern. We showed that these seed genes were strongly associated with cancer-associated signaling pathways and biological processes, the immune system, and the key cancer hallmarks. Further, the seed genes presented significant changes in their expression profiles in different cancer types and diverse mutation rates, and they also demonstrated high potential as diagnostic and prognostic biomarkers in various cancers. We report a number of seed genes that represent significant potential as systems biomarkers for understanding the pathobiology of tumorigenesis. Seed genes offer a new innovation avenue for potential applications toward cancer precision medicine in a broad range of cancers in oncology in the future.
dc.identifier.doi10.1089/omi.2021.0021
dc.identifier.endpage388
dc.identifier.issn1536-2310
dc.identifier.issn1557-8100
dc.identifier.issue6
dc.identifier.pmid34037481
dc.identifier.scopus2-s2.0-85108013959
dc.identifier.scopusqualityQ2
dc.identifier.startpage372
dc.identifier.urihttps://doi.org/10.1089/omi.2021.0021
dc.identifier.urihttps://hdl.handle.net/20.500.14669/2005
dc.identifier.volume25
dc.identifier.wosWOS:000654452000001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMary Ann Liebert, Inc
dc.relation.ispartofOmics-A Journal of Integrative Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241211
dc.subjectcancer stem cells
dc.subjectbiomarkers
dc.subjectcomputational systems biology
dc.subjectcancer precision medicine
dc.subjectoncology
dc.subjectbioinformatics
dc.subjectomics
dc.titleCancer Stem Cell Transcriptome Profiling Reveals Seed Genes of Tumorigenesis: New Avenues for Cancer Precision Medicine
dc.typeArticle

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