Annual and perennial Medicago show signatures of parallel adaptation to climate and soil in highly conserved genes

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dc.authoridsakiroglu, muhammet/0000-0002-7024-4348
dc.authoridAndrew, Rose/0000-0003-0099-8336
dc.authoridBlanco-Pastor, Jose Luis/0000-0002-7708-1342
dc.contributor.authorBlanco-Pastor, Jose Luis
dc.contributor.authorLiberal, Isabel M.
dc.contributor.authorSakiroglu, Muhammet
dc.contributor.authorWei, Yanling
dc.contributor.authorBrummer, E. Charles
dc.contributor.authorAndrew, Rose L.
dc.contributor.authorPfeil, Bernard E.
dc.date.accessioned2025-01-06T17:36:12Z
dc.date.available2025-01-06T17:36:12Z
dc.date.issued2021
dc.description.abstractHuman induced environmental change may require rapid adaptation of plant populations and crops, but the genomic basis of environmental adaptation remain poorly understood. We analysed polymorphic loci from the perennial crop Medicago sativa (alfalfa or lucerne) and the annual legume model species M. truncatula to search for a common set of candidate genes that might contribute to adaptation to abiotic stress in both annual and perennial Medicago species. We identified a set of candidate genes of adaptation associated with environmental gradients along the distribution of the two Medicago species. Candidate genes for each species were detected in homologous genomic linkage blocks using genome-environment (GEA) and genome-phenotype association analyses. Hundreds of GEA candidate genes were species-specific, of these, 13.4% (M. sativa) and 24% (M. truncatula) were also significantly associated with phenotypic traits. A set of 168 GEA candidates were shared by both species, which was 25.4% more than expected by chance. When combined, they explained a high proportion of variance for certain phenotypic traits associated with adaptation. Genes with highly conserved functions dominated among the shared candidates and were enriched in gene ontology terms that have shown to play a central role in drought avoidance and tolerance mechanisms by means of cellular shape modifications and other functions associated with cell homeostasis. Our results point to the existence of a molecular basis of adaptation to abiotic stress in Medicago determined by highly conserved genes and gene functions. We discuss these results in light of the recently proposed omnigenic model of complex traits.
dc.description.sponsorshipFP7 People: Marie-Curie Actions [625308]
dc.description.sponsorshipFP7 People: Marie-Curie Actions, Grant/Award Number: 625308
dc.identifier.doi10.1111/mec.16061
dc.identifier.endpage4465
dc.identifier.issn0962-1083
dc.identifier.issn1365-294X
dc.identifier.issue18
dc.identifier.pmid34217151
dc.identifier.scopus2-s2.0-85110494866
dc.identifier.scopusqualityQ1
dc.identifier.startpage4448
dc.identifier.urihttps://doi.org/10.1111/mec.16061
dc.identifier.urihttps://hdl.handle.net/20.500.14669/1802
dc.identifier.volume30
dc.identifier.wosWOS:000674217300001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofMolecular Ecology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241211
dc.subjectalfalfa
dc.subjectclimate
dc.subjectcomparative genomics
dc.subjectconserved genes
dc.subjectMedicago truncatula
dc.subjectomnigenic model
dc.titleAnnual and perennial Medicago show signatures of parallel adaptation to climate and soil in highly conserved genes
dc.typeArticle

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