Microfluidic vs. batch synthesis of fluorescent poly(GMA-co-EGDMA) micro/nanoparticles for biomedical applications

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dc.authoridKIBAR, GUNES/0000-0002-2586-6770
dc.contributor.authorKilincli, Betul
dc.contributor.authorCinar, Ayse Duru
dc.contributor.authorCetin, Barbaros
dc.contributor.authorKibar, Gunes
dc.date.accessioned2025-01-06T17:43:36Z
dc.date.available2025-01-06T17:43:36Z
dc.date.issued2024
dc.description.abstractFluorescent particles play a crucial role in nanomedicine and biological applications such as imaging, diagnostic tools, drug delivery, biosensing, multimodal imaging, and theranostics. This report presents a novel synthesis method and comparative study for synthesizing fluorescent particles in microfluidic continuous and batch-type reactors. Glycidyl methacrylate (GMA) and ethylene glycol dimethyl acrylate (EGDMA) are well-known monomers for synthesizing functional particles for biomedical applications. Several methods exist to obtain fluorescent poly(GMA-co-EGDMA) (p(GMA-EGDMA))particles through various polymerization techniques. Unlike existing methods, we developed a green approach for synthesizing fluorescent p(GMA-EGDMA) particles via UV-initiated one-step emulsion polymerization by comparing microfluidic and batch synthesis. Moreover, as a fluorescent dye, fluorescein isothiocyanate (FITC) was directly incorporated with p(GMA-EGDMA) particles at various concentrations to achieve tunable fluorescent functionality. While the batch synthesis resulted in polydisperse fluorescent p(GMA-EGDMA)microparticles with spherical shapes ranging from 25 mu m to 1.0 mu m in size, the microfluidic synthesis produced nonspherical nanoparticles. Fluorescent FITC@p(GMA-EGDMA) particles were characterized by scanning electron microscope (SEM), fluorescent microscope, and Fourier-transform infrared spectroscopy (FTIR). The synthesized particles have potential for fluorescence imaging applications, specifically bio-detection in array systems.
dc.description.sponsorshipTuerkiye Bilimsel ve Teknolojik Arascedil;timath;rma Kurumu Scientific and Technological Research Council of Turkiye [122C228, TUBITAK-2218]; Adana Alparslan Turkes Science and Technology University [22103005]; TUBITAK through the BICABA Program; Intern Researcher Scholarship Program [TUBITAK 2247-C STAR 2023/2]
dc.description.sponsorshipDr. G. Kibar would like to thank the financial support from the Scientific and Technological Research Council of Turkiye (TUBITAK-2218, Award Grand No.: 122C228) and Adana Alparslan Turkes Science and Technology University (Scientific Research Project, Grant No. 22103005). B. Kilincli also acknowledges the financial support provided by TUBITAK through the BICABA Program. A.D. Cinar extends gratitude to the Intern Researcher Scholarship Program (TUBITAK 2247-C STAR 2023/2) for their support. The authors give special thanks to Toprak Karaman for the 3D-printed platform for the experimental microfluidic synthesis setup and Reyhan Sever for preparing the mold photos of the microfluidic reactor.
dc.identifier.doi10.1007/s42247-024-00840-9
dc.identifier.issn2522-5731
dc.identifier.issn2522-574X
dc.identifier.scopus2-s2.0-85204766152
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1007/s42247-024-00840-9
dc.identifier.urihttps://hdl.handle.net/20.500.14669/2734
dc.identifier.wosWOS:001320306100004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringernature
dc.relation.ispartofEmergent Materials
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241211
dc.subjectMicroparticles
dc.subjectNanoparticles
dc.subjectUV-polymerization
dc.subjectEmulsion polymerization
dc.subjectMicroreactors
dc.subjectContinuous synthesis
dc.subjectGreen chemistry
dc.titleMicrofluidic vs. batch synthesis of fluorescent poly(GMA-co-EGDMA) micro/nanoparticles for biomedical applications
dc.typeArticle

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