Assessment of chitosan:gum tragacanth cryogels for tissue engineering applications

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dc.authoriddemir, didem/0000-0002-2977-2077
dc.authoridBolgen, Nimet/0000-0003-3162-0803
dc.authoridceylan, seda/0000-0002-1088-7886
dc.authoridSakim, Burcu/0000-0001-5345-4901
dc.authoridGenc, Rukan/0000-0002-9569-8776
dc.contributor.authorDemir, Didem
dc.contributor.authorUgurlu, Muge Asik
dc.contributor.authorCeylan, Seda
dc.contributor.authorSakim, Burcu
dc.contributor.authorGenc, Rukan
dc.contributor.authorBolgen, Nimet
dc.date.accessioned2025-01-06T17:36:58Z
dc.date.available2025-01-06T17:36:58Z
dc.date.issued2022
dc.description.abstractGum tragacanth is one of the most widely used natural gums in food, medicine, cosmetics and personal care products, and its use as polysaccharide-based scaffolds in tissue engineering applications has attracted great attention in recent years. The fabrication of pure gum tragacanth as a scaffold poses many challenges because of the high viscosity, poor mechanical properties and repulsive interaction between the polyanions. To overcome these, facilitate the formation of scaffolds and improve their final properties, chitosan and gum tragacanth were used together as natural, biocompatible and biodegradable polysaccharides. The scaffolds based on chitosan and gum tragacanth were successfully fabricated through cryotropic gelation and were characterized using different chemical, morphological, mechanical and biocompatibility analyses. All cryogel scaffolds exhibited a porous structure with an average diameter of 96.56-30.21 mu m, exhibiting high liquid absorption capacity, appropriate mechanical stability and controlled degradation behavior. According to the biocompatibility results, mouse embryonic fibroblast cells adhered well to the scaffolds and achieved high viability. The results are also discussed in the light of their potential usefulness as a scaffold for tissue engineering applications. (c) 2022 Society of Industrial Chemistry.
dc.description.sponsorshipScientific Research Projects Unit of Adana Alparslan Turke Science and Technology University [BAP-20103004]
dc.description.sponsorshipThe authors would like to acknowledge the Scientific Research Projects Unit of Adana Alparslan Turke Science and Technology University (BAP-20103004) for funding support of the cell experiments of this study.
dc.identifier.doi10.1002/pi.6372
dc.identifier.endpage1118
dc.identifier.issn0959-8103
dc.identifier.issn1097-0126
dc.identifier.issue9
dc.identifier.scopus2-s2.0-85124472286
dc.identifier.scopusqualityQ1
dc.identifier.startpage1109
dc.identifier.urihttps://doi.org/10.1002/pi.6372
dc.identifier.urihttps://hdl.handle.net/20.500.14669/2054
dc.identifier.volume71
dc.identifier.wosWOS:000751838900001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofPolymer International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241211
dc.subjectchitosan
dc.subjectgum tragacanth
dc.subjectcryogel
dc.subjectscaffold
dc.subjecttissue engineering
dc.titleAssessment of chitosan:gum tragacanth cryogels for tissue engineering applications
dc.typeArticle

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