A bi-layer electrospun polyurethane/silicone membrane scaffold: drug delivery and cytotoxicity studies

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dc.authoridceylan, seda/0000-0002-1088-7886
dc.authoridBolgen, Nimet/0000-0003-3162-0803
dc.contributor.authorMohsenzadeh, Elham
dc.contributor.authorDemir, Didem
dc.contributor.authorCeylan, Seda
dc.contributor.authorKhenoussi, Nabyl
dc.contributor.authorSchacher, Laurence
dc.contributor.authorAdolphe, Dominique
dc.contributor.authorBolgen, Nimet
dc.date.accessioned2025-01-06T17:44:36Z
dc.date.available2025-01-06T17:44:36Z
dc.date.issued2023
dc.description.abstractIn this study, a bi-layer scaffold combining polyurethane nanofibrous and silicone membrane layers was produced. Chemical, morphological and physical properties of the scaffolds were determined by Fourier-transform infrared spectroscopy, scanning electron microscope (SEM) and Brunauer-Emmett-Teller analyses, respectively. The surface properties were examined with the contact angle test. To evaluate the encapsulation and release behaviour of the scaffolds Rhodamine B and Nile red were used as model drugs. Further, the cytotoxicity and cell proliferation investigations were carried out using mouse embryonic fibroblasts cell lines. 3-(4,5-dimethylthiazoyl-2-yl)-2,5-diphenyltetrazolium bromide assay and SEM were used to investigate the cell viability and cell-scaffold interactions, respectively. The results of the study were evaluated in order to develop a bimodal drug release system that has the potential to be used in tissue engineering applications.
dc.identifier.doi10.1007/s12034-023-02975-7
dc.identifier.issn0250-4707
dc.identifier.issn0973-7669
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85162693310
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1007/s12034-023-02975-7
dc.identifier.urihttps://hdl.handle.net/20.500.14669/3118
dc.identifier.volume46
dc.identifier.wosWOS:001012467800003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherIndian Acad Sciences
dc.relation.ispartofBulletin of Materials Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241211
dc.subjectTissue engineering
dc.subjectelectrospinning
dc.subjectbi-layer scaffold
dc.subjectpolyurethane
dc.subjectsilicon
dc.titleA bi-layer electrospun polyurethane/silicone membrane scaffold: drug delivery and cytotoxicity studies
dc.typeArticle

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