Development of molecularly imprinted nanoparticles for the detection of cardiovascular diseases biomarker Angiotensin II in human serum

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dc.authoridBaydemir Pesint, Gozde/0000-0001-8668-8296
dc.authoridArisoy, Piril/0000-0001-8804-0960
dc.contributor.authorArisoy, Piril
dc.contributor.authorPesint, Gozde Baydemir
dc.date.accessioned2025-01-06T17:36:40Z
dc.date.available2025-01-06T17:36:40Z
dc.date.issued2025
dc.description.abstractAngiotensin II (Ang II) is a peptide hormone that causes vasoconstriction and an increase in blood pressure. Due to its relationship with cardiovascular diseases, it is an important biomarker in blood serum. In this study, Ang II imprinted nanoparticles were synthesized by miniemulsion polymerization reaction for the determination of Ang II from human serum. Hydroxyethyl methacrylate (HEMA) based Ang II imprinted (Ang II-MIPnp) and non-imprinted nanoparticles (NIPnp) were synthesized, characterized by zeta size analysis, scanning electron microscopy (SEM), transmission electron microscopy (TEM) and Fourier transform infrared spectrophotometer (FTIR-ATR). The average particle size of the NPs was recorded as 50 nm. Ang II molecules were successfully removed from the Ang II-MIPnp with a 98% success rate using 0.5 M NaCl solution to obtain template-specific cavities. Then, the adsorption studies were achieved. The binding capacity was found as 4500 pg. g(-1) at 700 pg. mL(-1) Ang II concentration. The selectivity studies showed that Ang II-MIPnp can recognize Ang II molecules 2.76 times and 3.23 times selectivity than Ang I and Vsp respectively. Reusability studies shows that the synthesized nanomaterial is reusable.
dc.description.sponsorshipAdana Alparslan Turkes Science and Technology University
dc.description.sponsorshipAdana Alparslan Turkes Science and Technology University, Grant/Award Number: TUB1
dc.identifier.doi10.1002/app.56304
dc.identifier.issn0021-8995
dc.identifier.issn1097-4628
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85204587977
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/app.56304
dc.identifier.urihttps://hdl.handle.net/20.500.14669/1950
dc.identifier.volume142
dc.identifier.wosWOS:001317754900001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Applied Polymer Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241211
dc.subjectbiomarker
dc.subjectcardiovascular diseases
dc.subjectmolecular imprinting
dc.subjectmolecular recognition
dc.subjectnanoparticles
dc.titleDevelopment of molecularly imprinted nanoparticles for the detection of cardiovascular diseases biomarker Angiotensin II in human serum
dc.typeArticle

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