Comparison of additive effects on the PVA/starch cryogels: Synthesis, characterization, cytotoxicity, and genotoxicity studies

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dc.authoriddemir, didem/0000-0002-2977-2077
dc.authoridBolgen, Nimet/0000-0003-3162-0803
dc.authoridceylan, seda/0000-0002-1088-7886
dc.authoridGokturk, Dilek/0000-0002-1195-5828
dc.authoridOzdemir Alkis, Meryem Damla/0000-0002-5728-8004
dc.contributor.authorCeylan, Seda
dc.contributor.authorGokturk, Dilek
dc.contributor.authorDemir, Didem
dc.contributor.authorOzdemir, M. Damla
dc.contributor.authorBolgen, Nimet
dc.date.accessioned2025-01-06T17:37:17Z
dc.date.available2025-01-06T17:37:17Z
dc.date.issued2018
dc.description.abstractThe research goal of this study is to produce suitable scaffolds for tissue engineering applications. Different ratios of polyvinyl alcohol (PVA)/starch (90:10, 70:30, 50:50) and crosslinking methods have been used to prepare cryogels. Chemically crosslinked cryogels were synthesized using glutaraldehyde as the crosslinking agent. For the physically crosslinked cryogels, sodium dodecyl sulfate was used during cryogelation as the foaming agent. Chemical structure and pore morphology were demonstrated by Fourier transform infrared spectroscopy and scanning electron microscopy (SEM). Swelling ratio and degradation profile of the scaffolds were also determined. 3-(4,5-dimethylthiazoyl-2-yl)-2,5-diphenyltetrazolium bromide assay and SEM were used to investigate the biocompatibility of the scaffolds and cell morphology. Genotoxicity test was performed to show DNA fragmentation. The overall results demonstrated that PVA/starch cryogels could have potentially appealing application as scaffolds for tissue engineering applications and additives affect the architecture and characteristic properties of the cryogels. [GRAPHICS] .
dc.identifier.doi10.1080/00914037.2017.1383254
dc.identifier.endpage864
dc.identifier.issn0091-4037
dc.identifier.issn1563-535X
dc.identifier.issue14
dc.identifier.scopus2-s2.0-85031128835
dc.identifier.scopusqualityQ1
dc.identifier.startpage855
dc.identifier.urihttps://doi.org/10.1080/00914037.2017.1383254
dc.identifier.urihttps://hdl.handle.net/20.500.14669/2180
dc.identifier.volume67
dc.identifier.wosWOS:000441159600005
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis As
dc.relation.ispartofInternational Journal of Polymeric Materials and Polymeric Biomaterials
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241211
dc.subjectCryogel
dc.subjectcytotoxicity
dc.subjectpolyvinyl alcohol
dc.subjectscaffold
dc.subjectstarch
dc.subjecttissue engineering
dc.titleComparison of additive effects on the PVA/starch cryogels: Synthesis, characterization, cytotoxicity, and genotoxicity studies
dc.typeArticle

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