Study on physiochemical structure and in vitro release behaviors of doxycycline-loaded PCL microspheres

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dc.authoridTezcaner, Aysen/0000-0003-4292-5856
dc.authoridAydin, Baran/0000-0001-7838-3708
dc.contributor.authorAydin, Ozlem
dc.contributor.authorAydin, Baran
dc.contributor.authorTezcaner, Aysen
dc.contributor.authorKeskin, Dilek
dc.date.accessioned2025-01-06T17:36:40Z
dc.date.available2025-01-06T17:36:40Z
dc.date.issued2015
dc.description.abstractThis study aimed to develop drug delivery system of doxycycline-loaded polycaprolactone (PCL) microspheres. The investigated microsphere formulation can be considered for local application in bone infections and degenerative joint diseases, which generally require long-term treatments via systemic drugs. PCL-14 kDa and 65 kDa were used in microsphere preparation. Before release, the microspheres were characterized by scanning electron microscopy, differential scanning calorimetry, and X-ray photoelectron spectroscopy. The mean particle size of microspheres was in the range of 74-122 mu m and their drug loadings ranged between 10 and 30%. In vitro release profiles were described using the Higuchi and the Korsmeyer-Peppas equations. Diffusion model was applied to experimental data for estimating diffusion coefficients of microspheres; calculated as between 4.5 x 10(-10) and 9.5 x 10(-10) cm(2)/s. Although long-term release from microspheres of PCL-14 kDa obeyed diffusion model, PCL-65 kDa microspheres showed this tendency only for some period. Modeling studies showed that the drug release mechanism was mainly dependent on loading and molecular weight differences. Release behavior of PCL-65 kDa microspheres, however, might be better represented by derivation of a different equation to model for the total release period. (c) 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41768
dc.description.sponsorshipMiddle East Technical University [METU-BAP-R07-02-12]
dc.description.sponsorshipThe authors would like to acknowledge the financial support provided by Middle East Technical University (Project No: METU-BAP-R07-02-12). The authors are also grateful to Dr. Utku Kanoglu for valuable contributions to the modeling studies.
dc.identifier.doi10.1002/app.41768
dc.identifier.issn0021-8995
dc.identifier.issn1097-4628
dc.identifier.issue14
dc.identifier.scopus2-s2.0-84921860340
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/app.41768
dc.identifier.urihttps://hdl.handle.net/20.500.14669/1943
dc.identifier.volume132
dc.identifier.wosWOS:000347695200020
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Applied Polymer Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241211
dc.subjectbiodegradable
dc.subjectdrug delivery systems
dc.subjectkinetics
dc.subjectproperties and characterization
dc.subjecttheory and modeling
dc.titleStudy on physiochemical structure and in vitro release behaviors of doxycycline-loaded PCL microspheres
dc.typeArticle

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