Study on physiochemical structure and in vitro release behaviors of doxycycline-loaded PCL microspheres
dc.authorid | Tezcaner, Aysen/0000-0003-4292-5856 | |
dc.authorid | Aydin, Baran/0000-0001-7838-3708 | |
dc.contributor.author | Aydin, Ozlem | |
dc.contributor.author | Aydin, Baran | |
dc.contributor.author | Tezcaner, Aysen | |
dc.contributor.author | Keskin, Dilek | |
dc.date.accessioned | 2025-01-06T17:36:40Z | |
dc.date.available | 2025-01-06T17:36:40Z | |
dc.date.issued | 2015 | |
dc.description.abstract | This study aimed to develop drug delivery system of doxycycline-loaded polycaprolactone (PCL) microspheres. The investigated microsphere formulation can be considered for local application in bone infections and degenerative joint diseases, which generally require long-term treatments via systemic drugs. PCL-14 kDa and 65 kDa were used in microsphere preparation. Before release, the microspheres were characterized by scanning electron microscopy, differential scanning calorimetry, and X-ray photoelectron spectroscopy. The mean particle size of microspheres was in the range of 74-122 mu m and their drug loadings ranged between 10 and 30%. In vitro release profiles were described using the Higuchi and the Korsmeyer-Peppas equations. Diffusion model was applied to experimental data for estimating diffusion coefficients of microspheres; calculated as between 4.5 x 10(-10) and 9.5 x 10(-10) cm(2)/s. Although long-term release from microspheres of PCL-14 kDa obeyed diffusion model, PCL-65 kDa microspheres showed this tendency only for some period. Modeling studies showed that the drug release mechanism was mainly dependent on loading and molecular weight differences. Release behavior of PCL-65 kDa microspheres, however, might be better represented by derivation of a different equation to model for the total release period. (c) 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41768 | |
dc.description.sponsorship | Middle East Technical University [METU-BAP-R07-02-12] | |
dc.description.sponsorship | The authors would like to acknowledge the financial support provided by Middle East Technical University (Project No: METU-BAP-R07-02-12). The authors are also grateful to Dr. Utku Kanoglu for valuable contributions to the modeling studies. | |
dc.identifier.doi | 10.1002/app.41768 | |
dc.identifier.issn | 0021-8995 | |
dc.identifier.issn | 1097-4628 | |
dc.identifier.issue | 14 | |
dc.identifier.scopus | 2-s2.0-84921860340 | |
dc.identifier.scopusquality | Q2 | |
dc.identifier.uri | https://doi.org/10.1002/app.41768 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14669/1943 | |
dc.identifier.volume | 132 | |
dc.identifier.wos | WOS:000347695200020 | |
dc.identifier.wosquality | Q2 | |
dc.indekslendigikaynak | Web of Science | |
dc.indekslendigikaynak | Scopus | |
dc.language.iso | en | |
dc.publisher | Wiley | |
dc.relation.ispartof | Journal of Applied Polymer Science | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.snmz | KA_20241211 | |
dc.subject | biodegradable | |
dc.subject | drug delivery systems | |
dc.subject | kinetics | |
dc.subject | properties and characterization | |
dc.subject | theory and modeling | |
dc.title | Study on physiochemical structure and in vitro release behaviors of doxycycline-loaded PCL microspheres | |
dc.type | Article |