Evaluation of the Relationship Between Thyroid Hormone Levels and Bisphenol A in Children Aged 6-14 Years

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dc.authoridHaytoglu, Zeliha/0000-0002-8371-5137
dc.authoridDA�LIO�LU, NEB�LE/0000-0003-3415-8159
dc.authoridALTUN YILDIRIM, P�nar/0000-0003-4013-1681
dc.authoridTURAN, IHSAN/0000-0002-5654-247X
dc.authoridMengen, Eda/0000-0003-1597-8418
dc.authoridATASOY AYDIN, Asl�/0000-0001-6901-7511
dc.authoridNazl�can, Ersin/0000-0002-1460-1996
dc.authoridNazl�can, Ersin/0000-0002-1460-1996
dc.contributor.authorYildirim, Pinar Altun
dc.contributor.authorNazlican, Ersin
dc.contributor.authorHaytoglu, Zeliha
dc.contributor.authorTuran, Ihsan
dc.contributor.authorKilincli, Betul
dc.contributor.authorAydin, Asli Atasoy
dc.contributor.authorMengen, Eda
dc.contributor.authorDaglioglu, Nebile
dc.date.accessioned2026-02-27T07:33:19Z
dc.date.available2026-02-27T07:33:19Z
dc.date.issued2025
dc.description.abstractBackgroundThe incidence of hypothyroidism in childhood is increasing. This study aimed to investigate the potential role of exposure to bisphenol A, an environmental endocrine disruptor, and its substitutes in the development of hypothyroidism. To this end, thyroid hormone levels and urinary bisphenol concentrations were compared in newly diagnosed hypothyroid children and a healthy control group. MethodsIn this case-control study, 51 newly diagnosed hypothyroid children aged 6-14 years were matched with 51 healthy controls. The association between thyroid hormone levels and urinary bisphenol levels was investigated by measuring urinary bisphenol levels in both the case and control groups. ResultsThere was no significant difference in age, sex or BMI percentile between the case and control groups. The groups were homogeneously distributed. When urinary bisphenol levels were examined, BPA, BPS, BPF and BPB were not detected in the control group. There was a significant difference between the groups in terms of urinary bisphenol BPS levels. The case group showed a mean total concentration of 16.5 ng/mL and a median of 5.8 ng/mL. Diagnosing hypothyroidism in the children can be considered by examining the bisphenol level. In the ROC analysis, if this level is over 1.3 and is considered positive for hypothyroidism, the sensitivity value is determined as 83.7% and the specificity value is 75%. ConclusionThis study demonstrated that at least 50% of the children in the case group had bisphenol concentrations exceeding the highest value recorded in the control group, suggesting that total BP levels could be used as a potential biomarker for hypothyroidism.
dc.description.sponsorshipCukurova University Scientific Research Projects Unit (BAP) [TTU-2022-15289]
dc.description.sponsorshipThe research was made possible through a research grant (TTU-2022-15289) awarded by the Cukurova University Scientific Research Projects Unit (BAP). Funds from this grant were utilized for data collection, data analysis, and the procurement of materials essential to the completion of the research project. The study was funded by the Cukurova University Scientific Research Projects Unit (BAP) with the number TTU-2022-15289. With this support, the materials used in data collection, evaluation and writing were provided.
dc.identifier.doi10.1111/cen.15221
dc.identifier.endpage105
dc.identifier.issn0300-0664
dc.identifier.issn1365-2265
dc.identifier.issue1
dc.identifier.pmid40025791
dc.identifier.startpage97
dc.identifier.urihttp://dx.doi.org/10.1111/cen.15221
dc.identifier.urihttps://hdl.handle.net/20.500.14669/4543
dc.identifier.volume103
dc.identifier.wosWOS:001435681900001
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofClinical Endocrinology
dc.relation.publicationcategoryMakale - Uluslararas� Hakemli Dergi - Kurum ��retim Eleman�
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20260302
dc.subjectbisphenol A
dc.subjectchildhood
dc.subjecthypothyroidism
dc.titleEvaluation of the Relationship Between Thyroid Hormone Levels and Bisphenol A in Children Aged 6-14 Years
dc.typeArticle

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