Expanding the role of exosomes in drug, biomolecule, and nanoparticle delivery

Basit Öğe Kaydı
dc.authoridKIBAR, GUNES/0000-0002-2586-6770
dc.authoridSAKA, Ongun Mehmet/0000-0002-8726-6391
dc.contributor.authorSaka, Ongun Mehmet
dc.contributor.authorDora, Devrim Demir
dc.contributor.authorKibar, Gunes
dc.contributor.authorTevlek, Atakan
dc.date.accessioned2026-02-27T07:33:26Z
dc.date.available2026-02-27T07:33:26Z
dc.date.issued2025
dc.description.abstractExosomes are nanoscale extracellular vesicles released by diverse cell types, serving essential functions in intercellular communication and physiological processes. These vesicles have garnered considerable interest in recent years for their potential as drug delivery systems, attributed to their natural origin, minimal immunogenicity, high biocompatibility, and capacity to traverse biological barriers, including the blood-brain barrier. Exosomes can be obtained from diverse biological fluids, rendering them accessible and versatile vehicles for therapeutic medicines. This study emphasizes the burgeoning significance of exosomes in drug administration, concentrating on their benefits, including improved stability, target selectivity, and the capacity to encapsulate various biomolecules, such as proteins, nucleic acids, and small molecules. Notwithstanding their potential applications, other problems remain, including as effective drug loading, industrial scalability, and the standardization of isolation methodologies. Overcoming these hurdles via new research is essential for fully harnessing the promise of exosomes in therapeutic applications, especially in the treatment of intricate diseases like cancer and neurological disorders.
dc.identifier.doi10.1016/j.lfs.2025.123499
dc.identifier.issn0024-3205
dc.identifier.issn1879-0631
dc.identifier.pmid39993468
dc.identifier.urihttp://dx.doi.org/10.1016/j.lfs.2025.123499
dc.identifier.urihttps://hdl.handle.net/20.500.14669/4571
dc.identifier.volume368
dc.identifier.wosWOS:001435031300001
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofLife Sciences
dc.relation.publicationcategoryMakale - Uluslararas� Hakemli Dergi - Kurum ��retim Eleman�
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20260302
dc.subjectExosomes
dc.subjectDrug delivery
dc.subjectBiomolecules
dc.subjectNanoparticles
dc.titleExpanding the role of exosomes in drug, biomolecule, and nanoparticle delivery
dc.typeArticle

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