Antimicrobial activity enhancement of PVA/chitosan films with the additive of CZTS quantum dots

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dc.authoridYurt, Fatma/0000-0002-9394-6908
dc.authoridceylan, seda/0000-0002-1088-7886
dc.authoridOZTURK, ISMAIL/0000-0002-2669-3090
dc.contributor.authorCeylan, Seda
dc.contributor.authorKucukosman, Ridvan
dc.contributor.authorYurt, Fatma
dc.contributor.authorOzel, Derya
dc.contributor.authorOztuerk, Ismail
dc.contributor.authorDemir, Didem
dc.contributor.authorOcakoglu, Kasim
dc.date.accessioned2025-01-06T17:37:18Z
dc.date.available2025-01-06T17:37:18Z
dc.date.issued2023
dc.description.abstractThe wound environment is a breeding ground for pathogens, and traditional wound dressing materials lack antibacterial properties. In this work, we aimed to develop PVA/chitosan (P/C)-based wound dressing scaffolds with anti-infective properties using Cu2ZnSnS4 quantum dots (CZTS QDs) to prevent infections in the wound. CZTS quantum dots were prepared by a simple hydrothermal process and characterized using appropriate techniques such as TEM, XRD, FTIR spectrum, and UV-Vis absorption spectroscopy. CZTS QDs were subsequently loaded at different concentrations onto PVA/chitosan membranes (0, 1.6, 2.5 and 3.3% w/w, based on the total polymer quantity). The chemical structure, contact angle and mechanical properties of the membranes were analyzed, and their antimicrobial activities and cell viability were also investigated. The cytocompatibility of the membranes and cell morphology was investigated using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and SEM. Based on studies on the interactions between membranes and cells, it was determined that incorporation of CZTS QDs into the membrane did not cause toxicity. To the best of our knowledge, this is the first report on loading CZTS QDs into membranes for tissue engineering applications, and the overall findings suggest that CZTS QDs-integrated membranes might have potentially appealing uses as antimicrobial films for wound healing.
dc.description.sponsorshipTarsus University Scientific Research Projects Coordination Department [MF.22.003]
dc.description.sponsorshipThe authors thank the Tarsus University Scientific Research Projects Coordination Department (Project no: MF.22.003) for the supports.
dc.identifier.doi10.1007/s00289-022-04615-2
dc.identifier.endpage11293
dc.identifier.issn0170-0839
dc.identifier.issn1436-2449
dc.identifier.issue10
dc.identifier.scopus2-s2.0-85142938628
dc.identifier.scopusqualityQ1
dc.identifier.startpage11273
dc.identifier.urihttps://doi.org/10.1007/s00289-022-04615-2
dc.identifier.urihttps://hdl.handle.net/20.500.14669/2185
dc.identifier.volume80
dc.identifier.wosWOS:000892917600001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofPolymer Bulletin
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241211
dc.subjectCu2ZnSnS4 quantum dots
dc.subjectCZTS
dc.subjectChitosan
dc.subjectPVA
dc.titleAntimicrobial activity enhancement of PVA/chitosan films with the additive of CZTS quantum dots
dc.typeArticle

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