Effects of Cu, Zn and their mixtures on bioaccumulation and antioxidant enzyme activities in Galleria mellonella L. (Lepidoptera: Pyralidae)

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dc.authoridTuncsoy, Benay/0000-0003-4361-3475
dc.authoridMESE, YAGMUR/0000-0002-3605-0689
dc.contributor.authorMese, Yagmur
dc.contributor.authorTuncsoy, Benay
dc.contributor.authorOzalp, Pinar
dc.date.accessioned2025-04-09T09:20:51Z
dc.date.available2025-04-09T09:20:51Z
dc.date.issued2022
dc.description.abstractThe effects of Cu, Zn and their mixture on bioaccumulation and antioxidant enzyme activities of midgut and fat body of Galleria mellonella larvae were investigated. Exposure to mixtures of both metals showed a synergistic effect and the accumulation levels were increased in both tissues. When the metals were exposed separately the concentration of Zn increased in both tissues, whereas the concentration of Cu increased in midgut and decreased in fat body. Also, it was determined that, oxidative stress occurred in the midgut and fat body when G. mellonella larvae were fed singly and in a mixture with different concentrations of Cu and Zn. In addition, significant changes were observed in antioxidant and detoxification enzyme activities, which are an indicator of oxidative stress. Larvae of G. mellonella showed immune responses similar to vertebrates, and could be used as bioindicator species due to being grown easily in the laboratory and reduced research costs Understanding the detoxification mechanism in insects is an important parameter for future ecotoxicological studies on the genotoxic, cytotoxic and physiological effects that different environmental pollutants such as heavy metals can cause.
dc.description.sponsorshipScientific Research Projects Coordination Unit of Cukurova University [FBA/2020/12547]
dc.description.sponsorshipThis study was supported by the Scientific Research Projects Coordination Unit of Cukurova University (FBA/2020/12547).
dc.identifier.doi10.1007/s10646-022-02531-9
dc.identifier.endpage656
dc.identifier.issn0963-9292
dc.identifier.issn1573-3017
dc.identifier.issue4
dc.identifier.pmid35296951
dc.identifier.scopus2-s2.0-85126349113
dc.identifier.scopusqualityQ2
dc.identifier.startpage649
dc.identifier.urihttps://doi.org/10.1007/s10646-022-02531-9
dc.identifier.urihttps://hdl.handle.net/20.500.14669/3422
dc.identifier.volume31
dc.identifier.wosWOS:000769838100002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofEcotoxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241211
dc.subjectAccumulation
dc.subjectAntioxidant enzyme
dc.subjectGalleria mellonella
dc.subjectHeavy metals
dc.titleEffects of Cu, Zn and their mixtures on bioaccumulation and antioxidant enzyme activities in Galleria mellonella L. (Lepidoptera: Pyralidae)
dc.typeArticle

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