Electrospun Composite Nanofibers Based on Poly (epsilon-Caprolactone) and Styrax Liquidus (Liquidambar orientalis Miller) as a Wound Dressing: Preparation, Characterization, Biological and Cytocompatibility Results

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dc.authoridceylan, seda/0000-0002-1088-7886
dc.authoridSakim, Burcu/0000-0001-5345-4901
dc.authoridBolgen, Nimet/0000-0003-3162-0803
dc.contributor.authorDemir, Didem
dc.contributor.authorOzdemir, Sadin
dc.contributor.authorCeylan, Seda
dc.contributor.authorYalcin, M. Serkan
dc.contributor.authorSakim, Burcu
dc.contributor.authorBolgen, Nimet
dc.date.accessioned2025-01-06T17:44:02Z
dc.date.available2025-01-06T17:44:02Z
dc.date.issued2022
dc.description.abstractIn this study, styrax liquidus (sweet gum balsam) extracted from Liquidambar orientalis Mill. incorporated PCL fibrous scaffolds were prepared using the electrospinning method. The effects of the styrax liquidus content on the prepared scaffolds were investigated using different physico-chemical and morphological analyses. Then, the styrax-loaded nanofibers were examined for their antioxidant activity, anti-biofilm, metal chelating, antimicrobial and DNA cleavage properties. The results obtained from these studies showed that the nanofibers exhibited effective biological activity depending on the weight ratio of the styrax liquidus. In light of the data obtained from the characterization and biological studies, a sample with high ratio of balsam was built for determining the cytocompatibility analysis in vitro. The cytotoxicity studies of the selected membrane were conducted using mouse embryonic fibroblast cells. The fibrous scaffolds lead to increase the cell number as a result of high viability. According to the results, we propose a novel biocompatible electrospun hybrid scaffold with antioxidant and antimicrobial properties that can be used as wound healing material for potential tissue engineering applications.
dc.identifier.doi10.1007/s10924-022-02376-7
dc.identifier.endpage2473
dc.identifier.issn1566-2543
dc.identifier.issn1572-8919
dc.identifier.issue6
dc.identifier.scopus2-s2.0-85123125995
dc.identifier.scopusqualityQ1
dc.identifier.startpage2462
dc.identifier.urihttps://doi.org/10.1007/s10924-022-02376-7
dc.identifier.urihttps://hdl.handle.net/20.500.14669/2890
dc.identifier.volume30
dc.identifier.wosWOS:000742251900001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofJournal of Polymers and The Environment
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241211
dc.subjectPoly (epsilon-caprolactone)
dc.subjectStyrax
dc.subjectLiquidambar orientalis Miller
dc.subjectNanofiber
dc.subjectWound dressing
dc.subjectTissue engineering
dc.titleElectrospun Composite Nanofibers Based on Poly (epsilon-Caprolactone) and Styrax Liquidus (Liquidambar orientalis Miller) as a Wound Dressing: Preparation, Characterization, Biological and Cytocompatibility Results
dc.typeArticle

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